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US 2026/0124249 A1Published application
Use of tnks inhibitors for regeneration of cartilage
AssigneeLiflex Science Inc.
InventorsJin-Hong Kim, Sukyeong Kim, Sangbin Han, Yongsik Cho
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Abstract
The present disclosure relates to a method of treating arthritis by targeting Tankyrase. The methods according to the present disclosure can be advantageously used for regeneration of cartilage tissue and for treating osteoarthritis by maximizing the matrix synthesis in cartilage by inhibition of Tankyrase and regulation of other proteins related therewith.
Claims13
A method of promoting differentiation of an adult stem cell into a cartilage cell comprising:
- treating the adult stem cell with an effective amount of an inhibitor of Tankyrase for promoting differentiation of the adult stem cell into the cartilage cell,
- wherein the inhibitor of Tankyrase stabilizes Sox9 protein or increases the concentration of Sox9 protein, and promotes chondrogenic differentiation of the adult stem cell into a chondrocyte.
Dependencies are inferred from the claim text.