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US 2026/0124140 A1Published application
Non-fouling or super stealth vesicle
AssigneeKawasaki Institute of Industrial Promotion
InventorsKazunori KATAOKA, Junjie LI
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Abstract
The disclosure provides non-fouling or super stealth vesicle that can be used for a drug delivery. The non-fouling or super stealth vesicle comprises polycation and polyanion, wherein the polycation and polyanion are neutralized in charge, and crosslinked to have a crosslinking degree over a certain level, and has a half-life (T1/2) over 24 hours in a blood or serum of the subject.
Claims21
A polyion complex, comprising polycation and polyanion,
- wherein the polycation has a positive charge, and comprises (i) a cationic polymer or a block copolymer comprising a cationic polymer block and optionally (ii) an uncharged hydrophilic polymer block,
- wherein the polyanion has a negative charge, and comprises (iii) an anionic polymer or a block copolymer comprising an anionic polymer block and optionally (iv) an uncharged hydrophilic polymer block,
- wherein the polycation and polyanion interact with each other to form the polyion complex,
- wherein the positive charge and the negative charge are neutralized in the polyion complex, and the ratio of the positive charge to the negative charge ranges between 0.95 and 1.05,
- wherein the polycation and polyanion are stabilized by crosslinking in the polyion complex and have a crosslinking density, and
- wherein the polyion complex has a half-life (T1/2) over 24 hours in a blood or serum of the subject.
3 more elements
Dependencies are inferred from the claim text.