System for Determining a Functional Fibrinogen Concentration

A system for determining a functional fibrinogen concentration from a patient's coagulating blood or blood plasma sample, the system comprising at least one processor configured to:

• obtain a signal representing physical or biochemical properties of the developing fibrin network during coagulation of the patient's blood or blood plasma sample over time, the signal being determined from the patient's coagulating blood or blood plasma sample;
• determine the functional fibrinogen concentration based on one or more values of one or more features of the signal with the help of a learned function which maps values of the one or more features to functional fibrinogen concentrations, the one or more features including at least one feature selected from a first set of features and/or multiple features selected from a larger set of features, the larger set of features comprising the first set of features and a second set of features,
• the first set of features including a feature related to a maximum value of the gradient of the signal and a feature related to the maximum of the second derivative of the signal, and
• the second set of features including a feature related to a difference between the maximum and the minimum of the signal and a feature related to the minimum of the second derivative of the signal;
• and
• output the functional fibrinogen concentration.