Particle hydrogel with excellent mechanical properties, and preparation method and use thereof

A preparation method of a particle hydrogel with improved mechanical properties, comprising following steps:

• S1, mixing a gelatin nanoparticle, an iron oxide nanoparticle, a calcium carbonate nanoparticle, and sodium alginate under alkaline conditions;
• and
• S2, adding a glucono-δ-lactone (GDL) powder for pH regulation to produce the particle hydrogel with the improved mechanical properties,
• wherein a preparation process of the gelatin nanoparticle in the step S1 comprises following steps:
• S111, dissolving a gelatin in deionized water under heating to produce a gelatin solution;
• adding acetone to the gelatin solution, and allowing to stand at room temperature for 1 h to produce a supernatant and a precipitate;
• discarding the supernatant;
• and dissolving the precipitate in deionized water, and conducting lyophilization to produce a lyophilized high-molecular-weight gelatin;
• and
• S112, dissolving the lyophilized high-molecular-weight gelatin obtained in the S111 in deionized water, and adjusting a pH with dilute hydrochloric acid to 2.5;
• under stirring, adding acetone dropwise to produce a gelatin dispersion;
• adding a glutaraldehyde solution to the gelatin dispersion at room temperature, and stirring for 16 h in the dark;
• adding an aqueous glycine solution, and stirring for 1 h;
• and conducting filtration and centrifugal washing to produce the gelatin nanoparticle;
• and
• a preparation process of the iron oxide nanoparticle in the step S1 comprises following steps:
• S121, adding 1.08 g of ferric chloride hexahydrate to a mixture of 10 mL of ethylene glycol and 30 mL of diethylene glycol, and stirring for 30 min to produce a first mixed solution;
• S122, adding 0.1 g of polyacrylic acid to the first mixed solution obtained in the S121, and stirring for 30 min to produce a second mixed solution;
• S123, adding 6 g of anhydrous sodium acetate to the second mixed solution obtained in the S122, and stirring for 1 h to produce a third mixed solution;
• and
• S124, adding the third mixed solution obtained in the S123 to a high-pressure reactor, and conducting a reaction at a high temperature to produce a black product;
• and subjecting the black product to centrifugal washing to produce the iron oxide nanoparticle,
• wherein the reaction in the S124 is conducted at 200° C. for 12 h.