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US 2026/0116990 A1Published application
Vhh antibodies and uses thereof
AssigneeKey2Brain AB
InventorsElisabet OHLIN SJÖSTRÖM, Magnus BERGLUND, Erik NORDLING, Mikael ÅSTRAND
Life of this patent
Estimating the term…
Abstract
The present invention relates to variable domain of heavy chain-only (VHH) antibody binding specifically to the transferrin receptor 1 (TfR1) and uses thereof to transport therapeutic agents or imaging agents into cells and over the blood-brain barrier.
Claims41
-39. (canceled)
A variable domain of heavy chain-only, VHH, antibody binding specifically to a transferrin receptor 1, TfR1, comprising:
- a complementarity determining region 1, CDR1, consisting of the amino acid sequence GX1X2FX3X4X5Y, wherein X1 is T or N, X2 is P, D or R, X3 is S, T or G, X4 is N, L, M or I, and X5 is N or E;
- a CDR2 consisting of the amino acid sequence FTX6X7GX8T as defined in SEQ ID NO:
- 1, wherein X6 is S, T or A, X7 is G, A, H, S or T, and X8 is S, N or D;
- and
- a CDR3 consisting of the amino acid sequence X9X10LX11X12, wherein X9 is Y or H, X10 is F or Y, X11 is D or G, and X12 is V, N or D.
2 more elements
A variable domain of heavy chain-only, VHH, antibody binding specifically to a transferrin receptor 1, TfR1, comprising:
- a complementarity determining region 1, CDR1, consisting of the amino acid sequence DSAFX28MNT as defined in SEQ ID NO:
- 38, wherein X28 is S or N;
- a CDR2 consisting of the amino acid sequence IVSDDNT as defined in SEQ ID NO:
- 39;
- and
- a CDR3 consisting of the amino acid sequence KGDVV as defined in SEQ ID NO:
- 40.
4 more elements
Dependencies are inferred from the claim text.