Microdevices and biosensor cartridges for biological or chemical analysis and systems and methods for the same
AssigneeIllumina, Inc.
InventorsHelmy A. Eltoukhy, Tarun Khurana, Behnam Javanmardi, Poorya Sabounchi, Majid Aghababazadeh
Life of this patent
Estimating the term…
Abstract
A flow cell including inlet and outlet ports in fluid communication with each other through a flow channel that extends therebetween. The flow channel includes a diffuser region and a field region that is located downstream from the diffuser region. The field region of the flow channel directs fluid along reaction sites where desired reactions occur. The fluid flows through the diffuser region in a first flow direction and through the field region in a second flow direction. The first and second flow directions being substantially perpendicular.
Claims12
1-53. (canceled)
A workstation for biological or chemical analysis, the workstation comprising:
- a workstation housing;
- a fluidic-control system at least partially positioned within the housing and comprising an upstream conduit for delivering fluid to a biosensor cartridge and a downstream conduit for removing the fluid from the biosensor cartridge;
- and
- a system receptacle configured to receive the biosensor cartridge, the system receptacle comprising:
- an alignment assembly configured to hold the biosensor cartridge m a predetermined orientation;
- upstream and downstream nozzles fluidicly coupled to the upstream and downstream conduits, respectively;
- and
- an actuation device configured to move the nozzles of the upstream and downstream conduits toward the alignment assembly in an axial direction to establish a fluidic connection with the biosensor cartridge.
A reservoir bag having top and bottom ends and a height extending therebetween, a gravitational force direction extending from the top end to the bottom end of the reservoir bag when in operation, the reservoir bag comprising:
- at least one flexible wall that defines a variable volume for holding a fluid, the volume comprising a main storage portion, a flow path portion, and a bridge portion, the main storage portion and the flow path portion being in fluid communication with each other through the bridge portion;
- a bag opening located proximate to the top end and opening onto the flow path portion, the fluid flowing through the bag opening when the fluid is removed;
- and
- a partition that projects from the top end toward the bottom end to a distal tip, the partition separating the main storage and flow path portions, the bridge portion being located between the distal tip and the bottom end.
A bioassay system configured to engage a microdevice for performing desired reactions and detecting activity that is indicative of the desired reactions, the bioassay system comprising:
- a system receptacle configured to engage the microdevice;
- a fluidic-control system configured to control a flow of fluid through the microdevice, the fluidic-control system being in fluid communication with the microdevice;
- a fluid storage system fluidicly coupled to the fluidic-control system, the fluid storage system providing reagents to be used for the desired reactions within the microdevice;
- a temperature control system configured to facilitate controlling a temperature of the environment within the microdevice;
- a user interface configured to receive user inputs from a user of the bioassay system;
- and
- a system controller configured to control operation of the fluidic-control, the fluid storage, and the temperature control systems, the system controller also configured to:
- receive the user inputs from the user interface, the user inputs relating to an assay protocol to run when the microdevice is engaged;
- and
- communicate detection data to the user interface, the user interface displaying the detection data to the user.
64-66. (canceled)
Dependencies are inferred from the claim text.