Intranasal knockout bolus

Abstract

The present disclosure describes intranasal knockout bolus formulations, methods, and devices. Olfactory delivery of a therapeutic agent via an intranasal bolus of the therapeutic agent may be reduced or terminated by precision delivery of a knockout bolus of a purging formulation. The knockout bolus may be delivered at a velocity sufficient to physically displace the therapeutic agent from an olfactory cleft, may dilute the intranasal bolus of a therapeutic formulation, or may cause an osmotic pressure sufficient to reverse a direction of a drug flow through a tissue of the olfactory cleft. An ability to modulate or stop delivery of the therapeutic agent via the olfactory cleft allows for more precision dosing and more control of dose timing in response to biometric monitoring.

Dependencies are inferred from the claim text.