Verteporfin Containing Silicone Topical Skin Adhesive for Wound Closure and Reduced Scarring
AssigneeCilag GmbH International
InventorsDuan OU, Mitra Vaseinasrabadi, Leo B. Kriksunov, Robert J. Tannhauser, Julian A. Quintero
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Abstract
The present invention is directed to topical skin adhesive formulations and kits for decreasing wound scarring comprising a rapidly curable two part liquid silicone formulation comprising a mixture of: Part A which comprises at least one vinyl terminated polydimethyl silicone base polymer, fumed silica particles, and a platinum catalyst capable of working at 20-40° C., Part B which comprises at least one vinyl terminated polydimethyl silicone base polymer and fumed silica particles, a cross-linker, a chain extender, and a medicant comprising verteporfin.
Claims18
A topical liquid silicone skin adhesive formulation having two co-reactive parts comprising:
- Co-reactive Part A comprising
- (A1) at least one vinyl terminated polydimethyl silicone base polymer in liquid form,
- (A2) fumed silica solid particles in silicone base polymer A1, and
- (A3) a platinum catalyst capable of catalyzing the reaction of silicone base polymer at 20-40° C.;
- and
- Co-reactive Part B comprising
- (B1) at least one vinyl terminated polydimethyl silicone base polymer in liquid form,
- (B2) fumed silica particles in silicone base polymer B1,
- (B3) a cross-linker to increase crosslink density upon reaction,
- (B4) a chain extender to effectively increase the molecular weight of the base silicone polymer by reaction, and
- (B5) verteporfin in solution.
Dependencies are inferred from the claim text.