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AssigneeBoston Scientific Scimed, Inc.
InventorsRick William Dorn, Joseph Thomas Delaney, JR., Cristian Parisi
Estimating the term…
In some aspects, the present disclosure pertains to multi-arm polymers that comprise a core region, a plurality of polymer arms linked to the core region, at least three of the polymer arms each comprising a hydrophilic polymer segment and an amino-alcohol residue that is attached to the hydrophilic polymer segment through an ether group, an electrophilic group attached to each amino-alcohol residue through a linkage that comprises a hydrolysable ester group, and a residue of a carboxylic-acid-containing iodinated molecule attached to each amino-alcohol residue through a linkage comprising an amide group. Other aspects of the present disclosure pertain to systems for forming hydrogels that are based on such multi-arm polymers, to crosslinked products that are formed from such systems, and to methods of treatment that use such systems.
A multi-arm polymer comprising a core region, a plurality of polymer arms linked to the core region, at least three of the polymer arms each comprising a hydrophilic polymer segment and an amino-alcohol residue that is attached to the hydrophilic polymer segment through an ether group, an electrophilic group attached to each amino-alcohol residue through a linkage that comprises a hydrolysable ester group, and a residue of a carboxylic-acid-containing iodinated molecule attached to each amino-alcohol residue through a linkage comprising an amide group.
A multi-arm polymer comprising a core region, a plurality of polymer arms linked to the core region, at least three of the polymer arms each comprising a hydrophilic polymer segment and a residue of a halogen-substituted cyclic anhydride that is attached to the hydrophilic polymer segment through a hydrolysable ester group, an electrophilic group attached to each halogen-substituted cyclic anhydride residue, and at least one residue of a hydroxyl-containing iodinated molecule attached to each halogen-substituted cyclic anhydride residue through a linkage comprising an ether group, wherein the halogen is selected from bromine and iodine.
A multi-arm polymer comprising a core region, a plurality of polymer arms linked to the core region, at least three of the polymer arms each comprising a hydrophilic polymer segment and a residue of a carboxylic-acid-substituted cyclic anhydride that is attached to the hydrophilic polymer segment through a hydrolysable ester group, a residue of a hydroxyl-containing iodinated molecule attached to each carboxylic-acid-substituted cyclic anhydride residue through a linkage that comprises a urethane group and an amide group, and an electrophilic group attached to each carboxylic-acid-substituted cyclic anhydride residue.
Dependencies are inferred from the claim text.