NEURONAL REGENERATION PROMOTING CELLS (NRPCs) AND TREATING DAMAGED NERVE CELLS
AssigneeCellatoz Therapeutics, Inc.
InventorsJaeseung LIM, Ho Jin KIM, Sung-Chul JUNG, Saeyoung PARK
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Abstract
The present disclosure provides new and innovative compositions of Neuronal regeneration-promoting cells (NRPCs), methods for generating NRPCs, and methods of treating subjects having damaged nerve cells using NRPCs. In an embodiment, the NRPCs are induced from tonsil-derived mesenchymal stem cells and express CD26, CD106, CD112, CD121a, and CD141, wherein CD121a has an expression level of about 30% or higher, the expression level measured immediately after thawing the NRPCs from a frozen state. Furthermore, the NRPCs are configured to promote formation of axons on neuronal cells.
Claims16
A plurality of cells induced from tonsil-derived mesenchymal stem cells and expressing CD26, CD106, CD112, CD121a, and CD141, wherein CD121a has an expression level of about 75% or higher.
The method of claim 14, wherein the method treats Charcot-Marie-Tooth (CMT) in the subject.
The method of claim 14, wherein the composition is administered immediately after thawing the cells from a frozen state.
The method of claim 17, wherein increasing the expression of miR-29a causes suppressing overexpression of peripheral myelin protein 22 (PMP22) at least in the localized area.
Dependencies are inferred from the claim text.