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US 2026/0115152 A1Published application
Agrimol b derivatives and methods of making and use thereof
AssigneeLaboratory for Synthetic Chemistry and Chemical Biology Limited
InventorsChi-Ming Che, Pui Kin Tony Lo
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Abstract
Agrimol B (“AGB”) derivatives that contain a sulfone moiety and show improved stability compared to its parent AGB are disclosed. In some forms, the AGB derivatives can possess anticancer properties that are comparable to its parent AGB. Methods for synthesizing the AGB derivatives using a sulfone intermediate or ketone/sulfone intermediate are disclosed. Methods of using the AGB derivatives for treating a cancer, such as large cell lung cancer, in a subject are also disclosed.
Claims20
A compound having the structure of:
- wherein:
- (i) R1 is an alkyl (e.g., an unsubstituted C1-C8 or C1-C6 alkyl, such as methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, cyclopentyl, or cyclohexyl) or
- wherein
- n1 is an integer from 1 to 5, and R7 is hydrogen, an alkyl, —O-alkyl, hydroxyl, or —NR′1R′2, wherein R′1 and R′2 are independently hydrogen or an alkyl;
- (ii) R2, R3, and R4 are independently hydrogen or an alkyl;
- and
- (iii) R5 and R6 are independently an alkyl, —C(O)—R12, or, wherein
- n2 is an integer from 1 to 5,
- R8 is hydrogen, hydroxyl, an alkyl, —O-alkyl, or —C(O)—R9,
- R9 and R12 are independently hydrogen, hydroxyl, an alkyl, or —O-alkyl, and
- at least one of R5 and R6 is
8 more elements
Dependencies are inferred from the claim text.