Ophthalmic compositions and methods for sustained drug release

Abstract

Embodiments of the disclosure provide ophthalmic compositions and methods of use thereof. The embodiments disclose ophthalmic compositions including devices such as a punctal plug. Some embodiments are directed to a method of preparing and using such devices. One embodiment provides a method of dissolving a hydrophilic polymer and an active pharmaceutical ingredient (API) in alcohol to form a hydrophilic polymer/API solution, where the API includes tacrolimus, spray drying the hydrophilic polymer/API solution to form a hydrophilic polymer/API mixture, mixing the hydrophilic polymer/API mixture with a binder to form an API paste, and curing the API paste to form a punctal plug, where the punctal plug is configured to release an effective amount of the API for a treatment period of 30 days to one year.

Dependencies are inferred from the claim text.