Arthrospira platensis non-parenteral therapeutic delivery platform
AssigneeLumen Bioscience, Inc.
InventorsJames ROBERTS, Michael TASCH, Mesfin GEWE, Benjamin JESTER, Tracy SAVERIA
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Abstract
The present disclosure provides non-parenteral compositions comprising a recombinant Spirulina comprising at least one exogenous therapeutic. Compositions of the present disclosure can be used as vaccines and/or therapeutic drugs. The present disclosure also provides methods of making recombinant Spirulina comprising at least one exogenous therapeutic, and methods of treatment.
Claims23
A composition comprising recombinant Spirulina encapsulating a plurality of VHH molecules or binding fragments thereof that bind to a C. difficile toxin, and wherein the plurality of VHH molecules or binding fragments thereof comprise:
- a) amino acid residues 26-32 (CDR1), 52-57 (CDR2), and 98-116 (CDR3) of SEQ ID NO:
- 5;
- b) amino acid residues 26-32 (CDR1), 52-56 (CDR2), and 98-100 (CDR3) of SEQ ID NO:
- 6;
- and
- c) amino acid residues 26-32 (CDR1), 52-56 (CDR2), and 98-105 (CDR3) of SEQ ID NO:
- 13.
A composition comprising recombinant Spirulina encapsulating:
- i) a plurality of VHH molecules or binding fragments thereof that bind to a C. difficile toxin, wherein the plurality of VHH molecules or binding fragments thereof comprise:
- a) amino acid residues 26-32 (CDR1), 52-57 (CDR2), and 98-116 (CDR3) of SEQ ID NO:
- 5;
- b) amino acid residues 26-32 (CDR1), 52-56 (CDR2), and 98-100 (CDR3) of SEQ ID NO:
- 6;
- and
- c) amino acid residues 26-32 (CDR1), 52-56 (CDR2), and 98-105 (CDR3) of SEQ ID NO:
- 13;
- and
- ii) a lysin.
Dependencies are inferred from the claim text.