Method and apparatus for preparing a tubular structure

A method of manufacturing a tubular biological structure, the method comprising:

• providing an apparatus comprising a tubular member configured to be rotated, wherein the tubular member comprises a tubular wall extending from a first end and a second end, wherein the tubular member comprises at least one opening through the tubular wall configured to allow egress of excess biological material, in use;
• feeding a first amount of a biological material on an internal surface of the tubular member;
• and
• rotating the tubular member.

A method of manufacturing a tubular multi-layered biological structure, the method comprising:

• (i) providing an apparatus comprising a tubular member configured to be rotated, wherein the tubular member comprises a tubular wall extending from a first end and a second end, wherein the tubular member comprises at least one opening through the tubular wall configured to allow egress of excess biological material, in use;
• (ii) feeding a first amount of a biological material on an internal surface of the tubular member;
• (iii) rotating the tubular member to form a first layer;
• (iv) optionally adding or feeding a first amount of gelation/crosslinking agent inside the tubular member to cause gelling and/or crosslinking of the first layer;
• and rotating the tubular member;
• (v) repeating steps (ii)-(vi) to form one or more additional layers.