Anti-cd137 antibodies
AssigneeEli Lilly and Company
InventorsChristopher Carl FRYE, Michael Dewain KALOS, Helen KOTANIDES, Stephanie Lynn SANDEFUR
Life of this patent
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Abstract
The present invention relates to antibodies that bind to human CDI37 and display agonist activity, and are useful for treating solid and hematological tumors alone and in combination with chemotherapy and ionizing radiation.
Claims33
An anti-human CD137 (SEQ ID NO:1) antibody comprising HCDR1 having the amino acid sequence of SEQ ID NO:
- 2, HCDR2 having the amino acid sequence of SEQ ID NO:
- 3, HCDR3 having the amino acid sequence of SEQ ID NO:
- 4, LCDR1 having the amino acid sequence of SEQ ID NO:
- 5, LCDR2 having the amino acid sequence of SEQ ID NO:
- 6, and LCDR3 having the amino acid sequence of SEQ ID NO:
- 7.
A mammalian cell capable of expressing an antibody comprising HCDR1 having the amino acid sequence of SEQ ID:
- 2, HCDR2 having the amino acid sequence of SEQ ID NO:
- 3, HCDR3 having the amino acid sequence of SEQ ID NO:
- 4, LCDR 1 having the amino acid sequence of SEQ ID NO:
- 5, LCDR2 having the amino acid sequence of SEQ ID NO:
- 6, and LCDR3 having the amino acid sequence of SEQ ID NO:7.
A mammalian cell capable of expressing an antibody comprising a heavy chain having the amino acid sequence of SEQ ID NO:
- 10 and a light chain having the amino acid sequence of SEQ ID NO:
- 11 or the amino acid sequence of SEQ ID NO:
- 13.
A process for producing an antibody comprising cultivating a mammalian cell capable of expressing the antibody and recovering the antibody;
- wherein the antibody comprises HCDR1 having the amino acid sequence of SEQ ID:
- 2, HCDR2 having the amino acid sequence of SEQ ID NO:
- 3, HCDR3 having the amino acid sequence of SEQ ID NO:
- 4, LCDR 1 having the amino acid sequence of SEQ ID NO:
- 5, LCDR2 having the amino acid sequence of SEQ ID NO:
- 6, and LCDR3 having the amino acid sequence of SEQ ID NO:
- 7.
A process for producing an antibody comprising cultivating a mammalian cell capable of expressing the antibody and recovering the antibody;
- wherein the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO:
- 10 and a light chain having the amino acid sequence of SEQ ID NO:
- 11 or the amino acid sequence of SEQ ID NO:
- 13.
A DNA molecule comprising a polynucleotide having the sequence of SEQ ID NO:
- 14 and one of SEQ ID NO:15, SEQ ID NO:16, or SEQ ID NO:17.
A DNA molecule comprising a polynucleotide having the sequence of SEQ ID NO:
- 14, SEQ ID NO:15, SEQ ID NO:
- 16, or SEQ ID NO:17.
Dependencies are inferred from the claim text.