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US 2026/0109765 A1Published application
Multi-specific antibodies with affinity for human a33 antigen and dota metal complex and uses thereof
OwnerSarah CHEAL, Hong XU +4inventors
InventorsSarah CHEAL, Hong XU, Steven LARSON, Nai-Kong CHEUNG, Karl Dane WITTRUP, Alice TZENG
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Abstract
Described herein are multi-specific binding agents that bind A33 and 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid. Also provided herein are methods of using multi-specific binding agents or compositions thereof for the detection, prevention, and/or therapeutic treatment of diseases characterized by expression of the A33 glycoprotein antigen, in particular, colorectal cancer.
Claims7
An isolated nucleic acid molecule encoding a light chain (LC) amino acid sequence selected from the group consisting of SEQ ID NO:
- 2, SEQ ID NO:
- 3 and SEQ ID NO:
- 4.
Dependencies are inferred from the claim text.