Compositions and methods for growth factor modulation
AssigneeScholar Rock, Inc.
InventorsThomas Schurpf, Nagesh K. Mahanthappa, Michelle Straub
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Abstract
Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and/or activities. In some embodiments, such growth factors are members of the TGF-β superfamily of proteins.
Claims46
A recombinant protein comprising one or more amino acid sequences selected from the group consisting of SEQ ID NOs:
- 1-40, 70, 71, 88, 89, 98-109, 116-142, 162-170 and a combination or fragment thereof.
A chimeric protein comprising one or more protein modules from at least two transforming growth factor (TGF)-β-related proteins, wherein said one or more protein modules are selected from the group consisting of a growth factor prodomain complex (GPC), a latency associated peptide (LAP), a LAP-like domain, a straight jacket region, a growth factor domain, a fastener region, a furin cleavage site region, an arm region, a fingers region, an N-terminal region for extracellular association, a latency loop, an alpha 1 helical region, an RGD sequence region, a trigger loop region, a bowtie region, a residue for LTBP association, a residue for GARP association, a bone morphogenetic protein (BMP)/Tolloid cleavage site and a protein module comprising any of the amino acid sequences of SEQ ID NOs:
- 38-97 or 171-198.
A method of selecting a desired antibody comprising the use of one or more assays, said one or more assays comprising one or more recombinant proteins, said one or more recombinant proteins comprising an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 1-40, 70, 71, 74, 75, 88, 90, 98-142, 162-170, 199-236, 273 and a combination or a fragment thereof.
Dependencies are inferred from the claim text.