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US 2026/0109720 A1Published application
Complexes and Compounds of Mercaptophenols and Curcumin for Therapeutic Applications
AssigneeSupratim Ghosh
InventorSUPRATIM GHOSH
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AssigneeSupratim Ghosh
InventorSUPRATIM GHOSH
Estimating the term…
Complexes and compounds of phenolic molecules possessing two or more ionizable groups, including curcumin, mercaptophenols, and structurally related derivatives, are disclosed. In certain embodiments, a metal or metalloid or nonmetallic atom is directly bonded to the α-carbon of curcumin or exclusively to the sulfur atom of a mercaptophenol, conferring enhanced aqueous solubility and stability under physiological and alkaline conditions. The invention includes compositions, processes for preparation, and therapeutic methods employing such complexes and compounds, which may form pharmaceutically acceptable salts suitable for biomedical applications, including parenteral or systemic administration. The complexes and compounds exhibit antiproliferative, anti-migratory, anti-invasive, and immune-stimulatory activities in cell-based and animal models and are suitable for treatment or management of conditions involving abnormal cell proliferation, pathogenic invasion, or dysregulated immune responses.
An organometallic compound of a curcumin-based molecule having an sp2-hybridized conjugated system, represented by formula I, wherein an α-carbon atom located between two consecutive ionizable keto/enol groups is bonded to a metal or metalloid M;
A complex and derivative comprising a mercaptophenol having an sp2-hybridized or conjugated system, represented by Formula II,
A complex or derivative of mercaptophenol that is soluble and stable in an aqueous or physiologically relevant medium at a concentration of 1.5-15 mM at 18-25° C. for 12 hours and exhibits antiproliferative, anti-migratory, anti-invasive, and immune-modulatory activity at 0.3-30 μM against malignant or disease-causing cells.
Dependencies are inferred from the claim text.