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US 2026/0109710 A1Published application
Synthesis of bromodomain inhibitors
AssigneeConstellation Pharmaceuticals, Inc.
InventorsLouis Plamondon, Jatin Patel, Yi Wang, Cuixiang Sun
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Abstract
Provided herein are processes which are useful for the preparation of small molecule bromodomain inhibitors.
Claims36
A process for preparing a compound having the Formula I:
- said method comprising reacting a compound having the Formula A:
- with a strong base in the presence of ethyl acetate followed by ester hydrolysis to form a compound having the Formula I.
A process for preparing a compound having the Formula II:
- said method comprising reacting a compound having the Formula I:
- with a compound having the Formula B:
- in the presence of a palladium source and a base.
The compound
- or a salt thereof.
A compound selected from:
- or a salt of any of the foregoing.
Dependencies are inferred from the claim text.