Heterocyclic compounds and uses thereof

A compound of Formula (III) or (IV):

• or a pharmaceutically acceptable salt or solvate thereof, wherein:
• W is C(R2)2;
• n is 0, 1, or 2;
• J1 is N and J2 is CH2;
• or J1 is C and J2 is CH;
• R1 is selected from halogen, —CN, C2-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, 2- to 6-membered heteroalkyl, 3- to 6-membered heteroalkenyl, 3- to 6-membered heteroalkynyl, —C0-6 alkyl-(C3-12 carbocycle), -(2- to 6-membered heteroalkyl)-(C3-12 carbocycle), —C0-6 alkyl-(3- to 12-membered heterocycle), -(2- to 6-membered heteroalkyl)-(3- to 12-membered heterocycle), —OR12, —SR12, —N(R12)(R13), —C(O)OR12, —OC(O)N(R12)(R13), —N(R12)C(O)N(R12)(R13), —N(R12)C(O)OR12, —N(R12)S(O)2R12, —C(O)R12, —S(O)R12, —OC(O)R12, —C(O)N(R12)(R13), —C(O)C(O)N(R12)(R13), —N(R12), —C(O)R12, —S(O)2R12, —S(O)(NR12)R12, —S(O)2N(R12)(R13), and —S(O)(NR12)N(R12)(R13), or (1) R1 and R2 attached to the same carbon atom are taken together to form oxo, =NR12, or ═C(R14)2, (2) R1 and R2, together with the atom(s) to which they are attached, form C3-12 carbocycle or 3- to 12-membered heterocycle, or (3) R1 and R3, together with the atoms to which they are attached, form 3- to 12-membered heterocycle, wherein C2-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, 2- to 6-membered heteroalkyl, 3- to 6-membered heteroalkenyl, 3- to 6-membered heteroalkynyl, —C0-6 alkyl-(C3-12 carbocycle), -(2- to 6-membered heteroalkyl)-(C3-12 carbocycle), —C0-6 alkyl-(3- to 12-membered heterocycle), -(2- to 6-membered heteroalkyl)-(3- to 12-membered heterocycle), C3-12 carbocycle, and 3- to 12-membered heterocycle are optionally substituted with one, two, or three R20;
• R2 is independently selected at each occurrence from hydrogen, halogen, —CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, 2- to 6-membered heteroalkyl, 3- to 6-membered heteroalkenyl, 3- to 6-membered heteroalkynyl, —C0-6 alkyl-(C3-12 carbocycle), -(2- to 6-membered heteroalkyl)-(C3-12 carbocycle), —C0-6 alkyl-(3- to 12-membered heterocycle), -(2- to 6-membered heteroalkyl)-(3- to 12-membered heterocycle), —OR12, —SR12, —N(R12)(R13), —C(O)OR12, —OC(O)N(R12)(R13), —N(R12)C(O)N(R12)(R13), —N(R12)C(O)OR12, —N(R12)S(O)2R12, —C(O)R12, —S(O)R12, —OC(O)R12, —C(O)N(R12)(R13), —C(O)C(O)N(R12)(R13), —N(R12), —C(O)R12, —S(O)2R12, —S(O)(NR12)R12, —S(O)2N(R12)(R13), and —S(O)(NR12)N(R12)(R13), optionally wherein one or both of (1) two R2 attached to the same carbon atom are taken together to form oxo, =NR12, or ═C(R14)2 and (2) two R2, together with the atom(s) to which they are attached, form C3-12 carbocycle or 3- to 12-membered heterocycle, wherein C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, 2- to 6-membered heteroalkyl, 3- to 6-membered heteroalkenyl, 3- to 6-membered heteroalkynyl, —C0-6 alkyl-(C3-12 carbocycle), -(2- to 6-membered heteroalkyl)-(C3-12 carbocycle), —C0-6 alkyl-(3- to 12-membered heterocycle), -(2- to 6-membered heteroalkyl)-(3- to 12-membered heterocycle), C3-12 carbocycle, and 3- to 12-membered heterocycle are optionally substituted with one, two, or three R20;
• R3 and R7 are independently selected from hydrogen, —CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, 2- to 6-membered heteroalkyl, 3- to 6-membered heteroalkenyl, 3- to 6-membered heteroalkynyl, —C0-6 alkyl-(C3-12 carbocycle), -(2- to 6-membered heteroalkyl)-(C3-12 carbocycle), —C0-6 alkyl-(3- to 12-membered heterocycle), -(2- to 6-membered heteroalkyl)-(3- to 12-membered heterocycle), (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl, —C(O)OR12, —C(O)O—(C1-6 alkyl)-OR15, —(C1-6 alkyl)-OR15, —C(O)R12, —C(O)N(R12)(R13), —C(O)C(O)N(R12)(R13), —S(O)2R12, —S(O)(NR12)R12, —S(O)2N(R12)(R13), and —S(═O)(=NR12)N(R12)(R13), wherein C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, —C0-6 alkyl-(C3-12 carbocycle), and —C0-6 alkyl-(3- to 12-membered heterocycle) are optionally substituted with one, two, or three R20;
• R4, R5, and R6 are independently selected from hydrogen, halogen, —CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, —OR12, —OR15, —O—(C1-6 alkyl)-OR15, —SR12, —N(R12)(R13), —C(O)OR12, —OC(O)N(R12)(R13), —N(R12)C(O)N(R12)(R13), —N(R12)C(O)OR12, —N(R12)S(O)2R12, —C(O)R12, —S(O)R12, —OC(O)R12, —C(O)N(R12)(R13), —C(O)C(O)N(R12)(R13), —N(R12), —C(O)R12, —S(O)2R12, —S(O)(NR12)R12, —S(O)2N(R12)(R13), and —S(O)(NR12)N(R12)(R13), wherein C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, and 3- to 10-membered heterocycle are optionally substituted with one, two, or three R20;
• L1 is absent or selected from C1-6 alkylene, C2-6 alkenylene, C2-6 alkynylene, 2- to 6-membered heteroalkylene, 3- to 6-membered heteroalkenylene, 3- to 6-membered heteroalkynylene, —C0-6 alkyl-(C3-12 carbocycle)-, -(2- to 6-membered heteroalkyl)-(C3-12 carbocycle)-, —C0-6 alkyl-(3- to 12-membered heterocycle)-, -(2- to 6-membered heteroalkyl)-(3- to 12-membered heterocycle)-, —O—, —S—, —N(R12)—, —C(NR12)—, —N(R12)C(NR12)—, —C(NR12)N(R12)—, —N(R12)C(NR12)N(R12)—, —C(O)O—, —OC(O)O—, —OC(O)N(R12)—, —N(R12)C(O)N(R12)—, —N(R12)C(O)O—, —C(O)N(R12)C(O)—, —C(O)N(R12)C(O)N(R12)—, —N(R12)S(O)2—, —C(O)—, —S(O)—, —OC(O)—, —C(O)N(R12)—, —C(O)C(O)N(R12)—, —N(R12)C(O)—, —S(O)2—, —OS(O)—, —S(O)O—, —OS(O)2—, —S(O)2O—, —S(O)(NR12)—, —S(O)2N(R12)—, —S(O)(NR12)N(R12)—, —N(R12)S(O)—, —S(O)N(R12)—, —N(R12)S(O)2N(R12)—, —N(R12)S(O)N(R12)—, —P(O)(OR12)—, and —P(O)(R12)—, wherein C1-6 alkylene, C2-6 alkenylene, C2-6 alkynylene, 2- to 6-membered heteroalkylene, 3- to 6-membered heteroalkenylene, 3- to 6-membered heteroalkynylene, —C0-6 alkyl-(C3-12 carbocycle)-, -(2- to 6-membered heteroalkyl)-(C3-12 carbocycle)-, —C0-6 alkyl-(3- to 12-membered heterocycle)-, and -(2- to 6-membered heteroalkyl)-(3- to 12-membered heterocycle)- are optionally substituted with one, two, or three R20;
• R12 is independently selected at each occurrence from hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, —C0-6 alkyl-(C3-12 carbocycle), and —C0-6 alkyl-(3- to 12-membered heterocycle), wherein C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, —C0-6 alkyl-(C3-12 carbocycle), and —C0-6 alkyl-(3- to 12-membered heterocycle) are optionally substituted with one, two, or three R20;
• R13 is independently selected at each occurrence from hydrogen, C1-6 alkyl, and C1-6 haloalkyl;
• or R12 and R13 attached to the same nitrogen atom form 3- to 10-membered heterocycle optionally substituted with one, two, or three R20;
• R14 is independently selected at each occurrence from hydrogen, halogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, —C0-6 alkyl-(C3-12 carbocycle), and —C0-6 alkyl-(3- to 12-membered heterocycle), or two R14 are taken together with the carbon atom to which they are attached to form C3-12 carbocycle or 3- to 12-membered heterocycle, wherein C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, —C0-6 alkyl-(C3-12 carbocycle), —C0-6 alkyl-(3- to 12-membered heterocycle), C3-12 carbocycle, and 3- to 12-membered heterocycle are optionally substituted with one, two, or three R20;
• R15 is independently selected at each occurrence from (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl, —C(O)R12, —C(O)OR12, —P(O)(X—R16)(Y—R17), and —CH2P(O)(X—R16)(Y—R17);
• X and Y are independently selected at each occurrence from —O— and —N(R12)—;
• R16 and R17 are independently selected at each occurrence from hydrogen, C1-6 alkyl, and phenyl, wherein C1-6 alkyl and phenyl are optionally substituted with one, two, or three substituents independently selected from halogen, —NO2, —CN, C3-12 carbocycle, 3- to 12-membered heterocycle, —OR12, —SR12, —N(R12)(R13), —C(O)OR12, —OC(O)N(R12)(R13), —N(R12)C(O)N(R12)(R13), —N(R12)C(O)OR12, —N(R12)S(O)2R12, —N(R12)S(O)2N(R12)(R13), —S—S—R12, —S—C(O)R12, —C(O)R12, —S(O)R12, —OC(O)R12, —OC(O)OR12, —C(O)N(R12)(R13), —C(O)C(O)N(R12)(R13), —N(R12), —C(O)R12, —S(O)2R12, —S(O)(NR12)R12, —S(O)2N(R12)(R13), —S(O)(NR12)N(R12)(R13), —P(O)(OR12)2, —P(O)(R12)2, —OP(O)(OR12)2, ═O, ═S, and =NR12;
• or R16 and R17 are taken together with the atoms to which they are attached to form 3- to 12-membered heterocycle optionally substituted with one, two, or three R20;
• R20 is independently selected at each occurrence from halogen, oxo, —CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, 2- to 6-membered heteroalkyl, 2- to 6-membered heteroalkenyl, 2- to 6-membered heteroalkynyl, —C0-6 alkyl-(C3-12 carbocycle), -(2- to 6-membered heteroalkyl)-(C3-12 carbocycle), —C0-6 alkyl-(3- to 12-membered heterocycle), -(2- to 6-membered heteroalkyl)-(3- to 12-membered heterocycle), —OR22, —SR22, —N(R22)(R23), =NR22, ═C(R21)2, —C(O)OR22, —OC(O)N(R22)(R23), —N(R22)C(O)N(R22)(R23), —N(R22)C(O)OR22, —N(R22)S(O)2R22, —C(O)R22, —S(O)R22, —OC(O)R22, —C(O)N(R22)(R23), —C(O)C(O)N(R22)(R23), —N(R22), —C(O)R22, —S(O)2R22, —S(O)(NR22)R22, —S(O)2N(R22)(R23)—, —S(═O)(=NR22)N(R22)(R23), and —OCH2C(O)OR22;
• wherein two R20 attached to the same or adjacent atoms optionally join to form C3-12 carbocycle or 3- to 12-membered heterocycle;
• wherein C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, 2- to 6-membered heteroalkyl, 2- to 6-membered heteroalkenyl, 2- to 6-membered heteroalkynyl, —C0-6 alkyl-(C3-12 carbocycle), -(2- to 6-membered heteroalkyl)-(C3-12 carbocycle), —C0-6 alkyl-(3- to 12-membered heterocycle), -(2- to 6-membered heteroalkyl)-(3- to 12-membered heterocycle), C3-12 carbocycle, and 3- to 12-membered heterocycle are optionally substituted with one or more substituents independently selected from halogen, oxo, —CN, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, —OR22, —SR22, —N(R22)(R23), =NR22, ═C(R21)2, —C(O)OR22, —OC(O)N(R22)(R23), —N(R22)C(O)N(R22)(R23), —N(R22)C(O)OR22, —N(R22)S(O)2R22, —C(O)R22, —S(O)R22, —OC(O)R22, —C(O)N(R22)(R23), —C(O)C(O)N(R22)(R23), —N(R22), —C(O)R22, —S(O)2R22, —S(O)(NR22)R22, —S(O)2N(R22)(R23), and —S(═O)(=NR22)N(R22)(R23);
• R21 is independently selected at each occurrence from hydrogen, halogen, C1-6 alkyl, C1-6 haloalkyl, —C0-6 alkyl-(C3-12 carbocycle), and —C0-6 alkyl-(3- to 12-membered heterocycle), or two R21 are taken together with the carbon atom to which they are attached to form C3-12 carbocycle or 3- to 12-membered heterocycle, each of which is optionally substituted with one, two, or three substituents independently selected from halogen, C1-3 alkyl, C1-3 haloalkyl, and —OH;
• R22 is independently selected at each occurrence from hydrogen, C1-6 alkyl, C1-6 haloalkyl, —C0-6 alkyl-(C3-12 carbocycle), and —C0-6 alkyl-(3- to 12-membered heterocycle);
• R23 is independently selected at each occurrence from hydrogen and C1-6 alkyl;
• or R22 and R23 attached to the same nitrogen atom form 3- to 10 membered heterocycle;
• and
• each independently indicates a single or double bond such that all valences are satisfied.