Process for manufacturing alogabat
AssigneeHoffmann-La Roche Inc.
InventorsMaud GUILLEMOT-PLASS, Christian JENNY, Matthias KOERNER, Isabelle Georgette Huguette MODOLO-CHELLAT, Michelangelo SCALONE
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Abstract
The invention relates to novel processes for manufacturing 6-[[5-methyl-3-(6-methyl-3-pyridyl)isoxazol-4-yl]methoxy]-N-tetrahydropyran-4-yl-pyridazine-3-carboxamide (1), or a pharmaceutically acceptable salt thereof. The processes according to the invention are particularly suitable for large-scale manufacturing of the compound of formula 1 under GMP conditions.
Claims21
A process for manufacturing alogabat (1), or a pharmaceutically acceptable salt thereof,
- comprising reacting [5-methyl-3-(6-methyl-3-pyridyl)isoxazol-4-yl]methanol (2)
- with 6-chloro-N-tetrahydropyran-4-yl-pyridazine-3-carboxamide (3)
- in the presence of a base, to afford said alogabat (1).
A process for manufacturing 6-chloro-N-tetrahydropyran-4-yl-pyridazine-3-carboxamide (3),
- comprising reacting 3,6-dichloropyridazine (4)
- with tetrahydro-2H-pyran-4-amine (5)
- and carbon monoxide in the presence of a base and a palladium catalyst to afford said 6-chloro-N-tetrahydropyran-4-yl-pyridazine-3-carboxamide (3).
A process for manufacturing alogabat (1), or a pharmaceutically acceptable salt thereof,
- comprising reacting 4-[(6-chloropyridazin-3-yl)oxymethyl]-5-methyl-3-(6-methyl-3-pyridyl)isoxazole (6)
- with tetrahydropyran-4-amine (7)
- and carbon monoxide in the presence of a base and a palladium catalyst to afford said alogabat (1).
The invention as described hereinbefore.
Dependencies are inferred from the claim text.