Novel antibiotic compound
OwnerAlexander WENTZEL, Kristin Fløgstad DEGNES +8inventors
InventorsAlexander WENTZEL, Kristin Fløgstad DEGNES, Giang-Son NGUYEN, Geir KLINKENBERG, Håvard SLETTA, Trond Erling ELLINGSEN, Mario Dino VAN DISSEL, Gilles VAN WEZEL, Marnix MEDEMA, Antonio FERNANDEZ-GUERRA
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Abstract
The present invention provides a new antibiotic compound termed nidaromycin derived from a new biosynthetic gene cluster (BGC), and its uses. Also provided herein are novel genes and nucleic acid molecules encoding the biosynthetic machinery for the production of nidaromycin, and to constructs, vectors, and host cells for expressing the BGC and methods for producing the compound.
Claims27
A compound of formula (I):
- wherein R1 is —SO2OH, —SO2OR or —SO2R and R2 is H, or wherein R2 is —SO2OH, —SO2OR or —SO2R and R1 is H;
- wherein R is a C1-C20 hydrocarbyl group;
- wherein each R3 is independently selected from H or a C1-C20 hydrocarbyl group;
- or a pharmaceutically acceptable salt, solvate or hydrate thereof.
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A nucleic acid molecule comprising:
- (a) a nucleotide sequence as shown in SEQ ID NO. 1;
- or
- (b) a nucleotide sequence which is the complement of SEQ ID NO. 1;
- or
- (c) a nucleotide sequence which is degenerate with SEQ ID NO. 1;
- or
- (d) a nucleotide sequence having at least 85% sequence identity with SEQ ID NO. 1;
- or
- (e) a part of any one of (a) to (d);
- wherein said nucleic acid molecule encodes or is complementary to a nucleic acid molecule encoding one or more polypeptides, or comprises or is complementary to a nucleic acid molecule comprising one or more genetic elements, having functional activity in the synthesis of an antibiotic compound.
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Dependencies are inferred from the claim text.