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US 2026/0109681 A1Published application
Process-scale synthesis of urolithin a
AssigneeAmazentis SA
InventorsWolfgang Skranc, George Yiannikouros, Alexander Trofimov, Zhixing Shan, Christopher Goss
Life of this patent
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Abstract
Disclosed are methods for preparing a salt of urolithin A and, in turn, urolithin A. The methods are advantageous for the large-scale preparation of urolithin A or a pharmaceutically acceptable salt thereof.
Claims21
-72. (canceled)
A method of preparing a salt of urolithin A, comprising:
- combining in an alkaline aqueous solution a copper-containing catalyst, 2-bromo-5-hydroxybenzoic acid, and resorcinol, thereby forming the salt of urolithin A,
- wherein the amount of the copper-containing catalyst is at least a trace amount but no more than 0.005 molar equivalents relative to the amount of 2-bromo-5 hydroxybenzoic acid.
A method of preparing a salt of urolithin A, comprising:
- combining in an alkaline aqueous solution a copper-containing catalyst, 2-bromo-5-hydroxybenzoic acid, and resorcinol, thereby forming the salt of urolithin A,
- wherein the alkaline aqueous solution is heated at a temperature in the range of about 60° C. to about 90° C.;
- and the salt of urolithin A is isolated by filtration.
Dependencies are inferred from the claim text.