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US 2026/0109675 A1Published application
Compositions and methods for adoptive cell therapy for cancer
AssigneeMemorial Sloan Kettering Cancer Center
InventorsDavid A. SCHEINBERG, Thomas J. GARDNER, Derek S. TAN, Jonghan LEE
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Abstract
Provided herein are compositions and methods for adoptive cell therapy comprising engineered immune cells that express a tumor antigen-targeted chimeric antigen receptor and a prodrug converting enzyme.
Claims12
A compound of Formula I
- or a zwitterion, pharmaceutically acceptable salt, and/or solvate thereof, where
- X1 is O or NH;
- X2 is N or CH;
- X3 is OH or H;
- W1 is H or NH—R3;
- two of R1, R2, and R3 are H and the remaining R1, R2, and R3 is
- X4 and X5 are each independently O or NH;
- X6 is O, NH, CH2, or C(Me)2;
- and
- R4, R5, R6, R7, and R8 are each independently H, —(CH2)3—NH(NH)—NH2, —(CH2)3—NH2, —(CH2)4—NH2, —CH2—C(O)OH, —(CH2)2—C(O)OH,
7 more elements
A compound of Formula II
- or a zwitterion, pharmaceutically acceptable salt, and/or solvate thereof, wherein
- X7 and X8 are each independently Cl, Br, I, O—S(O)2CH3, or O—S(O)2-tolyl;
- X9 is —C(O)—O, —C(O)—NH, O, or NH;
- R9 is a bond, alkylene, arylene, aralkylene, heteroarylene, or heteroaralkylene;
- R10 is
- X10 and X11 are each independently O or NH;
- X12 is O, NH, CH2, or C(Me)2;
- and
- R11, R12, R13, R14, and R15 are each independently H, —(CH2)3—NH(NH)—NH2, —(CH2)3—NH2, —(CH2)4—NH2, —CH2—C(O)OH, —(CH2)2—C(O)OH,
- provided that when X9 is O or NH, R9 is a phenylene, and R10 is
- then R11 and R13 are not —(CH2)2—C(O)OH.
8 more elements
A compound of Formula III
- or a zwitterion, pharmaceutically acceptable salt, and/or solvate thereof, wherein R30 is
- X35 and X36 are each independently O or NH;
- X37 is O, NH, CH2, or C(Me)2;
- and
- R31, R32, R33, R34, and R51 are each independently H, —(CH2)3—NH(NH)—NH2, —(CH2)3—NH2, —(CH2)4—NH2, —CH2—C(O)OH, —(CH2)2—C(O)OH,
- or a compound that is
- or a zwitterion, pharmaceutically acceptable salt, and/or solvate thereof.
4 more elements
Dependencies are inferred from the claim text.