Allosteric modulation of muscarinic acetylcholine receptor efficacy
AssigneesThe University of Toledo, The Penn State Research Foundation
InventorsWilliam S. Messer, JR., Hazel Cunningham, Corey Widman, John Ellis, Isaac Schiefer, Gina Kaup
Life of this patent
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Abstract
Allosteric modulators of muscarinic receptors, and methods of making and using the same, are described.
Claims27
A composition comprising Formula I:
- wherein:
- each X is, independently, H, F, Cl, Br, I, OCH3, CF3, or OCF3;
- R1 is selected from
- R2 is selected from either
- and
- R3 is H, F, Br, OCF3, OCH3,
- or a salt, stereoisomer, racemate, hydrate, solvate, polymorph, or prodrug thereof.
15-24. (canceled)
A method of modulating ACh activity at M1 muscarinic receptors, the method comprising contacting cells expressing M1 muscarinic receptors with an effective amount of a compound of Formula I to modulate ACh activity at the M1 muscarinic receptors expressed by the cells:
- wherein:
- each X is, independently, H, F, Cl, Br, I, OCH3, CF3, or OCF3;
- R1 is selected from
- R2 is selected from either
- and
- R3 is H, F, Br, OCF3,
26-31. (canceled)
33-44. (canceled)
A method of decreasing repetitive behaviors in a subject, the method comprising administering an effective amount of a compound of Formula I to a subject and decreasing repetitive behaviors in the subject:
- wherein:
- each X is, independently, H, F, Cl, Br, I, OCH3, CF3, or OCF3;
- R1 is selected from
- R2 is selected from either
- and
- R3 is H, F, Br, OCF3,
47-53. (canceled)
55-69. (canceled)
72-80. (canceled)
Dependencies are inferred from the claim text.