Compositions and methods for the treatment of viral infections
AssigneeCidara Therapeutics, Inc.
InventorsAllen BORCHARDT, Thomas P. BRADY, Zhi-Yong CHEN, Thanh LAM, Leslie W. TARI
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Abstract
Compositions and methods for the treatment of viral infections include conjugates containing inhibitors of viral neuraminidase (e.g., zanamivir, peramivir, or analogs thereof) linked to an Fc monomer, an Fc domain, and Fc-binding peptide, an albumin protein, or albumin-binding peptide. In particular, conjugates can be used in the treatment of viral infections (e.g., influenza viral infections).
Claims20
1-46. (canceled)
A method for the prophylactic treatment of a viral infection, the method comprising administering to the subject a conjugate described by formula (D-II-6):
- wherein each E comprises an Fc domain monomer;
- n is 1 or 2;
- T is an integer from 1 to 20;
- L is a linker;
- each R7 is independently C1-C20 alkyl;
- and
- the squiggly line indicates that L is covalently attached to E;
- or a pharmaceutically acceptable salt thereof.
A method for the prophylactic treatment of a viral infection in a subject in need thereof, the method comprising administering to the subject a conjugate described by the structure:
- wherein J is an Fc domain comprising two Fc domain monomers;
- T is an integer from 1 to 20,
- L is a linker;
- each R7 is independently C1-C20 alkyl;
- and
- the squiggly line indicates that L is covalently attached to J;
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.