Auto-tuning drug regulator constructions

Abstract

The present invention provides a regulator construct in which the drug efficacy is auto-regulated by the presence of a indicator enzyme. The construct is a chemical structure comprising: (a) a biorecognition component comprising a substrate recognized by an enzyme, (b) an incapacitation component, and (c) an active drug component. The incapacitation component provides a chemical incapacitation mechanism to render benign or incapacitate the drug component, after the substrate-enzyme interaction, allowing additionally for the creation of altered benign chemical structures while, otherwise, when said enzymes is inactive or absent the drug will take effect.

Dependencies are inferred from the claim text.