Optimized epicutaneous vaccination

A method for providing a vaccination against a pathogen in a subject in need thereof, which comprises:

• performing skin micro-perforation in a skin area in the subject to form one or more micropores, the skin micro-perforation not altering the basal layer of the epidermis and the one or more micropores extending from the surface of the skin through one or several epidermis layers, but without extending to the dermis, and
• then epicutaneously administering an antigen from the pathogen on said skin area of the subject by means of a skin patch, wherein:
• the skin patch is occlusive and comprises a backing suitable to create a hermetically closed condensation chamber on skin, and
• the antigen is deposited on the skin facing side of said backing, in dry form, and optionally in combination with one or more pharmaceutically acceptable excipients.