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US 2026/0108583 A1Published application
Compositions and methods for intranasal delivery of therapeutic peptides
AssigneeFinitus, LLC
InventorsSpencer Bouhadir, Jacob J. Miguel
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Abstract
The present disclosure provides, inter alia, compositions and methods for intranasal delivery of peptides.
Claims56
An intranasal spray composition comprising:
- a peptide
- a thickening agent;
- a cyclodextrin (CD);
- and
- a surfactant;
- wherein the peptide and cyclodextrin form an inclusion complex and are encapsulated by the surfactant;
- wherein the peptide, CMC, CD, and non-ionic surfactant are effective to produce a stable population of particles.
4 more elements
A method of treating a subject with a therapeutic formulation comprising the step of intranasally administering a composition comprising:
- a peptide
- a thickening agent;
- a cyclodextrin (CD);
- and
- a surfactant;
- wherein the peptide and cyclodextrin form an inclusion complex and are encapsulated by the surfactant;
- wherein the peptide, CMC, CD, and non-ionic surfactant are effective to produce a stable population of particles.
4 more elements
A method for delivery of a peptide to the central nervous system of a subject by intranasal administration comprising the step of:
- providing to the subject a compositions comprising a peptide;
- a thickening agent;
- a cyclodextrin (CD);
- and
- a surfactant;
- wherein the peptide and cyclodextrin form an inclusion complex and are encapsulated by the surfactant;
- wherein the peptide, CMC, CD, and non-ionic surfactant are effective to produce a stable population of particles.
4 more elements
Dependencies are inferred from the claim text.