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US 2026/0108581 A1Published application
Compositions and methods for microsphere delivery of carnosine for treatment of neurodegenerative diseases and disorders
AssigneeFinitus, LLC
InventorsSpencer Bouhadir, Jacob J. Miguel
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Abstract
The present disclosure provides, inter alia, compositions and methods for microsphere delivery of carnosine for treatment of neurodegenerative diseases or conditions.
Claims30
A method of treating or ameliorating a neurodegenerative disease or condition in a subject in need thereof comprising the step of administering to the subject a microsphere formulation comprising:
- a plurality of microspheres comprising carnosine;
- a biodegradable polymer;
- and cyclodextrin;
- wherein the carnosine is entrapped by the biodegradable polymer and cyclodextrin;
- and
- wherein the microspheres have an average size of less than 100 μm.
3 more elements
A microsphere effective for treatment of a neurodegenerative disease or condition produced by the steps of:
- providing an aqueous phase comprising carnosine in an aqueous polyvinyl alcohol (PVA) solution;
- providing an organic phase comprising a poly(lactic-co-glycolic) acid (PLGA) polymer and cyclodextrin in a dichloromethane (DCM) solution;
- combining the organic phase with the aqueous phase to produce a primary emulsion;
- providing an external aqueous PVA solution;
- combining the primary emulsion with the external aqueous PVA solution to produce a double emulsion;
- and
- evaporating the solvents to produce the microsphere formulation, wherein the microspheres have an average size of less than 100 μm.
4 more elements
(canceled)
Dependencies are inferred from the claim text.