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US 2026/0108467 A1Published application
Compositions and methods for microsphere delivery of therapeutic peptides
AssigneeFinitus, LLC
InventorsSpencer Bouhadir, Jacob J. Miguel
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Abstract
The present disclosure provides, inter alia, compositions and methods for microsphere delivery of peptides for treatment of diseases or conditions.
Claims57
A microsphere formulation for delivery of a therapeutic peptide comprising:
- a plurality of microspheres comprising a peptide;
- a biodegradable polymer;
- and a cyclodextrin;
- wherein the peptide is entrapped by the biodegradable polymer and cyclodextrin;
- and
- wherein the microspheres have an average size of less than 100 μm.
3 more elements
A microsphere effective for delivery of a therapeutic peptide to a subject in need thereof produced by the process of:
- providing an aqueous phase comprising peptide in an aqueous solution;
- providing an organic phase comprising a biodegradable polymer and cyclodextrin in an organic solution;
- combining the organic phase with the aqueous phase to produce a primary emulsion;
- providing an external aqueous phase;
- combining the primary emulsion with the external aqueous phase to produce a double emulsion;
- and
- evaporating the solvents to produce the microsphere formulation.
4 more elements
A method of making a microsphere effective for delivery of a therapeutic peptide in a subject in need thereof comprising the steps of:
- providing an aqueous phase comprising peptide in an aqueous solution;
- providing an organic phase comprising a biodegradable polymer and cyclodextrin in an organic solution;
- combining the organic phase with the aqueous phase to produce a primary emulsion;
- providing an external aqueous phase;
- combining the primary emulsion with the external aqueous phase to produce a double emulsion;
- and
- evaporating the solvents to produce the microsphere formulation.
4 more elements
Dependencies are inferred from the claim text.