Method in Bioprocess System

A bioreactor or a chromatography system configured to estimate performance of a bioprocess material used therein, the bioprocess material comprising at least two ingredients, each having data properties, wherein the bioreactor or chromatography system is configured to perform the steps of:

• i) obtaining the data properties for the at least two ingredients used to produce the bioprocess material,
• ii) defining procedures to produce the bioprocess material based on the obtained data properties for the at least two ingredients used to produce the bioprocess material,
• iii) processing the at least two ingredients according to the defined procedures to obtain at least one product,
• iv) measuring data properties of each product,
• v) calculating data properties of each product which are different from the measured data properties of each product based on the measured data properties of each product and data properties from the at least two ingredients, and
• vi) if the product is the bioprocess material, processing the measured and calculated data properties to estimate the impact of the bioprocess material on a target product in the bioreactor or chromatography system, or
• vii) if the product is not the bioprocess material, treating the product as an intermediate material and repeating steps iii)-vi) with each product as one of the at least two ingredients, wherein the calculated data properties in step v) and the measured data properties in step iv) are the data properties for each product used as one of the at least two ingredients.