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US 2026/0103699 A1Published application
Capture And Selective Release Of Biological Material
AssigneeIllumina, Inc.
InventorsAaron Aslanian, Jian-Sen Li, Ali Asadi, Xin Sheng
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Abstract
A biological material complex is described herein. In some embodiments, the biological material complex includes a solid surface having a terminal hydrazine that is available to bind to a functional group of a biological material. Applications, uses, and variations of the disclosed complex include, but are not limited to, separating, purifying, and labeling biological materials.
Claims20
A biological material complex comprising:
- a solid surface;
- and
- a linker coupled to the solid surface at a first end of the linker and a terminal hydrazine or hydrazide coupled to a second end of the linker.
A method of preparing a biological material complex, comprising:
- hybridizing a first end of a linker to a solid surface to form a biological material substrate, wherein the linker comprises a terminal hydrazine at a second end of the linker;
- providing a biological material to a volume including the biological material substrate, wherein the biological material substrate comprises a terminal aldehyde;
- and
- linking the biological material and the biological material substrate via a reaction between the terminal hydrazine and the terminal aldehyde.
1 more element
A linked biological material complex, comprising:
- a solid surface;
- a linker coupled to the solid surface at a first end of the linker and a terminal hydrazine coupled to a second end of the linker, and wherein the linker comprises an electron withdrawing group;
- and
- a biological material coupled to the second end of the linker via a hydrazone, wherein the hydrazone is adjacent to the electron withdrawing group.
1 more element
Dependencies are inferred from the claim text.