Synovium-on-a-Chip
AssigneeNew York University
InventorsWeiqiang Chen, Chao Ma, Benteng Ma, Theresa Wampler Muskardin
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Abstract
A synovium on a chip device having: a cartridge housing, a central chamber embedded in the cartridge housing, at least one aperture fluidly connected to the central chamber, and a plurality of evenly spaced micropillars arranged in a substantially circular shape within the central chamber such that the central chamber is partitioned into at least a first inner region and a first outer region, wherein the first inner region includes endothelial cells configured to mimic a vascular network and the first outer region includes fibroblast-like synoviocytes (FLS) configured to mimic a synovium.
Claims18
A synovium on a chip device, comprising:
- a cartridge housing;
- a central chamber embedded in the cartridge housing;
- at least one aperture fluidly connected to the central chamber;
- and
- a plurality of evenly spaced micropillars arranged in a substantially circular shape within the central chamber such that the central chamber is partitioned into at least a first inner region and a first outer region;
- wherein the first inner region comprises endothelial cells configured to mimic a vascular network and the first outer region comprises fibroblast-like synoviocytes (FLS) configured to mimic a synovium.
Dependencies are inferred from the claim text.