Antimicrobial and/or antiadhesive crosslinking agents and antimicrobial and/or antiadhesive medical hydrogels formed therefrom

An antimicrobial cross-linked reaction product of:

• (a) a multi-arm polymer comprising a core, a plurality of polymer segments having a first end that is covalently attached to the core and a second end comprising a moiety that comprises a reactive group;
• and (b) an antimicrobial multifunctional compound that comprises functional groups that are reactive with the reactive group of the multi-arm polymer, wherein the antimicrobial multifunctional compound comprises ε-poly-l-lysine n-acyl, ε-poly-l-lysine, ε-poly-l-lysine hydrochloride, ε-poly-l-lysine hydrobromide, ε-poly-l-lysine hydrofluoride, ε-poly-l-lysine hydroiodide, quaternized ε-poly-l-lysine, or any combination thereof, and wherein a molar ratio of the antimicrobial compound to the multi-arm polymer is in a range from about 0.2:1 to about 10:1.

A system for forming a hydrogel that comprises (a) a quaternary-amine-containing polyamino compound that comprises a quaternary-amine-containing moiety that comprises a quaternary amine group and a polyamino moiety that comprise a plurality of primary amine groups;

• and (b) a reactive polymer comprising a plurality of reactive moieties, wherein the reactive moieties are reactive with the plurality of primary amine groups of the quaternary-amine-containing polyamino compound, and wherein the quaternary-amine-containing moiety is coupled to the polyamino moiety through a linkage that comprises an amide group.