Paracrine Adenoviral Delivery of Biomolecules
AssigneeUniversitäT ZüRich
InventorsKaren Patricia HARTMANN, Andreas PLÜCKTHUN
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Abstract
Disclosed herein are designed ankyrin repeat domain specifically binding to fibroblast activation protein (FAP). Such designed ankyrin repeat domains can be used in recombinant adapter molecules that are displayed on adenoviruses. Adenoviruses armed with such adapters efficiently transduce human fibroblasts and significantly broaden treatment opportunities through paracrine delivery of cargo to the tumor microenvironment (TME).
Claims18
A recombinant protein capable of mediating the transduction of FAP-positive cells comprising
- a) a first designed ankyrin repeat domain specifically binding to FAP,
- b) a second designed ankyrin repeat domain specifically binding to the knob of an adenovirus, and
- c) a trimerization domain.
13-14. (canceled)
A recombinant protein comprising an ankyrin repeat domain specifically binding to FAP, wherein said ankyrin repeat domain comprises an amino acid sequence selected from the group consisting of SEQ ID No. 5-28.
Dependencies are inferred from the claim text.