Back to results
US 2026/0103464 A1Published application
Cyclopropyl-(hetero)aryl-substituted ethylsulphonyl-pyridine derivatives
AssigneesBoehringer Ingelheim Vetmedica GmbH, Nihon Nohyaku Co., Ltd.
InventorsBart HERLÉ, Hannes Fiepko KOOLMAN, Alan LONG, Robin MEIER, Ikki YONEMURA, Julien Gagnepain
Life of this patent
Estimating the term…
Abstract
Disclosed herein are intermediate compounds that form cyclopropyl-(hetero)aryl substituted ethylsulphonyl-pyridine derivatives, where such derivatives are useful as antiparasitic agents for the treatment, prevention and/or control of parasitic infections and/or infestations in animals.
Claims21
A compound selected from the group consisting of formula (II) or formula (III):
- wherein:
- W1, W2, W3, W4, W5 are each independently N, C or C—H, and at most three of W1, W2, W3, W4, W5 are N;
- is attached to a C atom;
- R, R1a, R1b, R2a, R2b, R3 are each independently hydrogen, halogen, C1-C6-alkyl, C1-C6-haloalkyl, C3-C8-cycloalkyl, aryl, C1-C6-alkoxy, C1-C6-haloalkoxy, OH, CN, C(O)ORv, S(O)r—(C1-C6-alkyl), S(O)s—(C1-C6-haloalkyl), S(O)t—Rw, S(O)2—N(Rx)(Ry), S(O)—(Rw)═N—Rz, wherein R3, if present once or more times, in each occurrence is independently attached to a C atom, or wherein R together with R1a or R1b forms an unsubstituted or substituted carbocycle or an unsubstituted or substituted heterocycle, and such carbocycle or heterocycle if substituted is independently substituted with one, two or three substituents each independently selected from the group consisting of halogen, alkyl, C1-C6-haloalkyl, C3-C8-cycloalkyl, aryl, C1-C6-alkoxy, C1-C6-haloalkoxy, OH, CN, C(O)ORx, S(O)r—(C1-C6-alkyl), and S(O)s—(C1-C6-haloalkyl);
- Rv, Rw, Rx, Ry, Rz in each occurrence are independently selected from the group consisting of hydrogen, halogen, C1-C6-alkyl, and C1-C6-haloalkyl;
- n is 0, 1, 2, 3, 4;
- r, s, t in each occurrence independently are 0, 1 or 2;
- the dashed bond () signifies a single or double bond;
- and
- Z is halogen, C(O)—OH, C(O)-halogen, or C(O)—O—(C1-C6)-alkyl;
- or a pharmaceutically acceptable salt thereof.
8 more elements
A compound according to formula (IV):
- wherein:
- W1, W2, W3, W4, W5 are each independently N, C or C—H, and at most three of W1, W2, W3, W4, W5 are N;
- is attached to a C atom;
- R, R1a, R1b, R2a, R2b, R3 are each independently hydrogen, halogen, C1-C6-alkyl, C1-C6-haloalkyl, C3-C8-cycloalkyl, aryl, C1-C6-alkoxy, C1-C6-haloalkoxy, OH, CN, C(O)ORv, S(O)r—(C1-C6-alkyl), S(O)s—(C1-C6-haloalkyl), S(O)t—Rw, S(O)2—N(Rx)(Ry), S(O)—(Rw)═N—Rz, wherein R3, if present once or more times, in each occurrence is independently attached to a C atom, or wherein R together with R1a or R1b forms an unsubstituted or substituted carbocycle or an unsubstituted or substituted heterocycle, and such carbocycle or heterocycle if substituted is independently substituted with one, two or three substituents each independently selected from the group consisting of halogen, alkyl, C1-C6-haloalkyl, C3-C8-cycloalkyl, aryl, C1-C6-alkoxy, C1-C6-haloalkoxy, OH, CN, C(O)ORx, S(O)r—(C1-C6-alkyl), and S(O)s—(C1-C6-haloalkyl);
- Rv, Rw, Rx, Ry, Rz in each occurrence are independently selected from the group consisting of hydrogen, halogen, C1-C6-alkyl, and C1-C6-haloalkyl;
- n is 0, 1, 2, 3, 4;
- r, s, t in each occurrence independently are 0, 1 or 2;
- the dashed bond () signifies a single or double bond;
- and
- Z′ is B(OH)2, Sn(CH3)3, halogen, or
7 more elements
Dependencies are inferred from the claim text.