Estrogen receptor modulators and uses thereof

A compound of Formula I:

• or a pharmaceutically acceptable salt thereof, wherein:
• A is selected from optionally substituted 5-membered heteroaryl comprising 1-3 heteroatoms selected from N, O, and S, wherein at least 1 heteroatom is S or O, optionally substituted 7- to 10-membered bicyclic heteroaryl comprising 1-4 heteroatoms selected from N, O, and S, and optionally substituted 3- to 6-membered heterocyclyl comprising 1-3 heteroatoms selected from N, O, and S;
• L is a covalent bond or an optionally substituted bivalent group selected from —O—C0-C5 aliphatic- and —C1-C5 aliphatic-O—;
• B is selected from 3- to 12-membered heterocyclyl comprising 1-3 heteroatoms selected from N, O, and S and C3-C6 cycloaliphatic;
• R1 is selected from hydrogen and optionally substituted C1-C6 aliphatic;
• R2 is selected from hydrogen and optionally substituted C1-C6 aliphatic;
• R3 is selected from hydrogen, halogen, —CN, —ORa, —C(O)Ra, —C(O)ORa, —OC(O)Ra, —C(O)N(Ra)2, —OC(O)N(Ra)2, —NO2, —N(Ra)2, —N(Ra)C(O)Ra, —N(Ra)C(O)ORa, —N(Ra)S(O)2Ra, —SRa, —S(O)2Ra, —S(O)N(Ra)2, —S(O)2N(Ra)2, and an optionally substituted C1-6 aliphatic group;
• each R4 is independently halogen, —CN, —ORa, —N(Ra)2, —C(O)Ra, —OC(O)Ra, —C(O)ORa, —C(O)N(Ra)2, —N(Ra)C(O)Ra, or an optionally substituted group selected from C1-C6 aliphatic and 3- to 12-membered heterocyclyl comprising 1 to 3 heteroatoms selected from N, O, and S;
• each Ra is independently selected from hydrogen and optionally substituted C1-C6 aliphatic;
• and
• n is 0 to 5.