Modified Tetracyclines for Treatment of Alcohol Use Disorder, Pain and Other Disorders Involving Potential Inflammatory Processes

A modified tetracycline molecule, pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, and tautomers thereof selected from formulas 1 to 85:

• wherein the doxycycline, minocycline, and tigecycline structures are modified to prevent binding of the molecule to a ribosome.

A pharmaceutical composition comprising a compound of Formula 1 to 85, pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, and tautomers thereof in an amount effective to treat a Substance Use Disorder and one or more pharmaceutically acceptable excipients.

A method of treating Alcohol Use Disorder (AUD), Substance Use Disorder (SUD), tobacco use, pain, or proinflammatory disorders comprising:

• providing the subject with an effective amount of one or more modified tetracyclines of Formula 1 to 85 to ameliorate or eliminate the AUD, SUD, pain, or proinflammatory disorder and that reduced, or no, antimicrobial activity.

A method of treating Alcohol Use Disorder (AUD), Substance Use Disorder (SUD), tobacco use, pain, or proinflammatory disorders comprising:

• identifying a subject in need of treatment for at least one of AUD, SUD, pain, or a proinflammatory disorder;
• and
• providing the subject with an effective amount of one or more modified tetracyclines of Formula 1 to 85 to ameliorate or eliminate the AUD, SUD, pain, or proinflammatory disorder and that reduced, or no, antimicrobial activity in a pharmaceutically acceptable excipient.