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AssigneeLonghorn Vaccines and Diagnostics, LLC
InventorsJeffrey D. Fischer, Clara J. Sei, Gerald W. Fischer
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The invention is directed to immunological compositions of one or more peptides containing epitopes of PGN, LTA and LPS molecules that induce an immunological response in a mammal, and to multiple antibodies that bind to these epitopes. Immunological compositions and antibodies disclosed herein can be used in the treatment and/or prevention of human health disorders such as bacterial sepsis, inflammation, cancers, tumors, inflammatory diseases and disorders, and neurodegenerative disorders such as, but not limited to Alzheimer's disease, frontotemporal dementia, chronic traumatic encephalopathy (CTE), Lewy body dementia and/or limbic predominant age-related TDP-43 encephalopathy (LATE).
A composition comprising a peptide sequence containing a combination of epitopes and/or mimotopes from a plurality of the molecules selected from the group consisting of peptidoglycan (PGN), lipoteichoic acid (LTA), and lipopolysaccharide (LPS).
A method for prevention and/or treatment of a neurodegeneration of mammalian brain tissue comprising administering a peptide sequence containing a combination of epitopes and/or mimotopes of peptidoglycan (PGN), lipoteichoic acid (LTA), and/or lipopolysaccharide (LPS), or antibodies that are reactive to epitopes or mimotopes of peptidoglycan (PGN), lipoteichoic acid (LTA), and/or lipopolysaccharide (LPS).
A method for prevention and/or treatment of an abnormal proliferation of cells comprising administering a peptide sequence containing a combination of epitopes and/or mimotopes of peptidoglycan (PGN), lipoteichoic acid (LTA), and/or lipopolysaccharide (LPS), or antibodies that are reactive to epitopes or mimotopes of peptidoglycan (PGN), lipoteichoic acid (LTA), and/or lipopolysaccharide (LPS) to a subject.
A method for prevention and/or treatment of an inflammation comprising administering a peptide sequence containing a combination of epitopes and/or mimotopes of peptidoglycan (PGN), lipoteichoic acid (LTA), and/or lipopolysaccharide (LPS), or antibodies that are reactive to epitopes or mimotopes of peptidoglycan (PGN), lipoteichoic acid (LTA), and/or lipopolysaccharide (LPS) to a subject.
A method for prevention and/or treatment of sepsis comprising a peptide sequence containing a combination of epitopes and/or mimotopes of peptidoglycan (PGN), lipoteichoic acid (LTA), and/or lipopolysaccharide (LPS), or antibodies that are reactive to a plurality of epitopes or mimotopes of peptidoglycan (PGN), lipoteichoic acid (LTA), and/or lipopolysaccharide (LPS).
A method for prevention and/or treatment of a neurodegeneration of mammalian brain tissue in a subject comprising:
Dependencies are inferred from the claim text.