Compositions and methods utilizing a novel human foxo3 isoform
AssigneeNew York Society for the Relief of the Ruptured and Crippled, maintaining the Hospital for Special S
InventorBaohong Zhao
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Abstract
Provided herein is a method of suppressing osteoclast differentiation or function and/or bone resorption or destruction in a subject in need thereof and compositions therefore. In one embodiment, the method includes increasing the amount, expression, or activity of Foxo3 isoform 2 in the subject.
Claims16
A method of suppressing osteoclast differentiation or function and/or bone resorption or destruction in a subject in need thereof, comprising increasing the amount, expression, or activity of Foxo3 isoform 2 in the subject.
A method of treating a skeletal disease in a subject in need thereof, the method comprising increasing the amount, expression, or activity of Foxo3 isoform 2 in the subject.
A method of assessing the efficacy of a treatment comprising measuring the level of Foxo3 isoform 2 in the blood of a subject receiving treatment, wherein an increase in the level of Foxo3 isoform 2 indicates effectiveness of the treatment for treating a skeletal disease.
A method of diagnosing an increased risk of developing a skeletal disease in a subject, the method comprising measuring the level of Foxo3 isoform 2 in the blood of a subject receiving treatment, wherein a decrease in the level of Foxo3 isoform 2 as compared to a control level indicates a greater risk of developing a skeletal disease.
A method of diagnosing a skeletal disease in a subject, the method comprising measuring the level of Foxo3 isoform 2 in the blood of a subject receiving treatment, wherein a decrease in the level of Foxo3 isoform 2 as compared to a control level indicates the presence of a skeletal disease.
Dependencies are inferred from the claim text.