Inhibition of a tripartite vor protein complex in multicellular organisms
AssigneesAurelio Lorico, Mark Santos, Germana Rappa, Patrizia Diana, Giuseppe Pizzorno, Andrea Dagnino, Ottavio Dagnino, Baldesare Renda, Gaspare Spedale, Technische UniversitäT Dresden, Basck Invest Limited
InventorsAurelio LORICO, Denis CORBEIL, Mark SANTOS, Germana RAPPA
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Abstract
The present disclosure relates generally to methods of inhibiting a tripartite VAP-A, ORP3 and Rab7 (VOR) protein complex in multicellular organisms, to methods of identifying agents which inhibit such complex and to the medical use of those agents. Inhibition of the VOR complex causes interference with at least one mechanism of intercellular communication, wherein the intercellular communication is mediated by receptor-ligand interaction and/or EVs, and viral infection involving the transport of endocytosed biomaterials to the nucleus of recipient cells.
Claims15
A method for identifying an agent which inhibits the tripartite VOR protein complex, wherein the method comprises contacting at least one eukaryotic cell having the tripartite VOR protein complex with the chemical agent under conditions suitable for binding, and detecting the integrity of the tripartite VOR protein complex and/or consequence of loss of the tripartite VOR protein complex.
A tripartite VOR protein complex inhibitor agent for use in medicine.
Dependencies are inferred from the claim text.