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US 2026/0098490 A1Published application
Polymeric vascular grafts which induce neovascularization with mild to minimal inflammation and promotion of fibrovascular tissue
AssigneeVenostent, Inc.
InventorTimothy C. Boire
Life of this patent
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Abstract
The present invention relates generally to shape memory polymer devices that are porous. The porosity of the device may generate advantageous neovascularization, decrease inflammation, and decrease fibrosis. The device may include a surface having a pore size of 400 μm-1200 μm and a pore spacing of about 100 μm to about 750 μm.
Claims20
An implantable tissue supporting device comprising:
- a biodegradable polymeric scaffold configured to surround both a native blood vessel and a vascular graft at an anastomosis site, wherein the scaffold comprises a first region and a second region, the first region configured to be positioned proximal to the native blood vessel, the first region having a first pore size of about 500 μm to about 1200 μm and a first pore spacing of about 200 μm to about 500 μm, the second region configured to be positioned proximal to the vascular graft, the second region having a second pore size of about 500 μm to about 1200 μm and a second pore spacing of about 500 μm to about 800 μm, and wherein the scaffold comprises crosslinked polymers including a first monomer that is allyl-functionalized and a second monomer that is &-caprolactone.
An implantable tissue supporting device comprising:
- a biodegradable polymeric scaffold capable of surrounding a tissue, wherein the scaffold comprises crosslinked polymers including poly(ε-caprolactone)-co-(α-allyl carboxylate ε-caprolactone), and wherein the scaffold has a pore size of about 500 μm to about 1000 μm, a pore spacing of about 500 μm to about 800 μm, and wherein the device has a Young's modulus at 37° C. of about 0.05 MPa to about 200 MPa and is mechanically compliant at physiological temperature.
Dependencies are inferred from the claim text.