A modified protein scaffold and use thereof

Protein comprising an amino acid sequence of SEQ ID NO:

• 115, where the variable positions in the amino acid sequence of SEQ ID NO:
• 115 are limited in such a way that
• x1 to x4, x58, x57, and x56 may be variable or absent,
• x6 to x11, x13, x15 to x20, x24 to x29, x31 to x32, x34, x39, x41 to x42, x44, x46 to x50, x52 to x54 may be variable,
• x21 is F, Y, or W,
• x22 is Y or F,
• x23 is Y or F,
• x35 is Y or W,
• x36 is G or S,
• x40 is G or A,
• x43 is N or G, and
• x45 is F or Y;
• characterized in that said protein
• i) has an amino acid sequence segment of general formula Ih-mod, starting at position 12 and ending at position 19 of SEQ ID NO:
• 115:
• GX1CX1VX2X3X4X5, (Ih-mod)
• where
• X1 is any of F, Y, L, P, Q, M, V, W, A, or T,
• X1V is R, or K,
• X2 is any of A, G, S, or T,
• X3 is any amino acid of the 17-set, where the 17-set comprises A, I, L, F, or Y,
• X4 is any of K, I, Q, R, H, S, F, M, N, L, or V, and
• X5 is any ofR, V, I, K, M, Q, E, F, L, N, Y, D, S, H;
• and
• ii) in position 34 of the amino acid sequence of SEQ ID NO:
• 115 it contains any amino acid of the 34-set, where the 34-set comprises Y, I, F, G, V and S;
• and salts, esters and pharmaceutically acceptable prodrugs of said protein.