Vaccine compositions and uses thereof
AssigneeCentivax, Inc.
InventorsJacob Glanville, Rishi Bedi, Nicholas Bayless, Sangil Kim, Gusti Zeiner, Sawsan Youssef
Life of this patent
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Abstract
The present disclosure provides vaccine compositions comprising a plurality of distinct antigens. Also provided are nucleic acid vaccine composition comprising one or more nucleic acids encoding for a plurality of distinct antigens. The plurality of distinct antigens comprises a combination of influenza antigens. The vaccine composition can be formulated for delivery as a mRNA/LNP, a recombinant protein, a virus-like particle (VLP), or DNA. Methods of preventing an influenza infection and methods of inducing an immune response are also disclosed.
Claims21
-219. (canceled)
A vaccine composition comprising a plurality of distinct antigens, the vaccine composition comprising:
- (a) an antigen comprising an amino acid sequence corresponding to SEQ ID NO:
- 3 or a sequence at least 90% identical to SEQ ID NO:
- 3;
- (b) an antigen comprising an amino acid sequence corresponding to SEQ ID NO:
- 16 or a sequence at least 90% identical to SEQ ID NO:
- 16;
- (c) an antigen comprising an amino acid sequence corresponding to SEQ ID NO:
- 18 or a sequence at least 90% identical to SEQ ID NO:
- 18;
- (d) an antigen comprising an amino acid sequence corresponding to SEQ ID NO:
- 19 or a sequence at least 90% identical to SEQ ID NO:
- 19;
- (e) an antigen comprising an amino acid sequence corresponding to SEQ ID NO:
- 21 or a sequence at least 90% identical to SEQ ID NO:
- 21;
- (f) an antigen comprising an amino acid sequence corresponding to SEQ ID NO:
- 24 or a sequence at least 90% identical to SEQ ID NO:
- 24;
- (g) an antigen comprising an amino acid sequence corresponding to SEQ ID NO:
- 39 or a sequence at least 90% identical to SEQ ID NO:
- 39;
- (h) an antigen comprising an amino acid sequence corresponding to SEQ ID NO:
- 40 or a sequence at least 90% identical to SEQ ID NO:
- 40;
- (i) an antigen comprising an amino acid sequence corresponding to SEQ ID NO:
- 41 or a sequence at least 90% identical to SEQ ID NO:
- 41;
- and
- (j) an antigen comprising an amino acid sequence corresponding to SEQ ID NO:
- 42 or a sequence at least 90% identical to SEQ ID NO:
- 42.
A nucleic acid vaccine composition comprising one or more nucleic acids encoding for a plurality of distinct antigens, wherein the plurality of distinct antigens comprises:
- (a) an antigen comprising an amino acid sequence corresponding to SEQ ID NO:
- 3 or a sequence at least 90% identical to SEQ ID NO:
- 3;
- (b) an antigen comprising an amino acid sequence corresponding to SEQ ID NO:
- 16 or a sequence at least 90% identical to SEQ ID NO:
- 16;
- (c) an antigen comprising an amino acid sequence corresponding to SEQ ID NO:
- 18 or a sequence at least 90% identical to SEQ ID NO:
- 18;
- (d) an antigen comprising an amino acid sequence corresponding to SEQ ID NO:
- 19 or a sequence at least 90% identical to SEQ ID NO:
- 19;
- (e) an antigen comprising an amino acid sequence corresponding to SEQ ID NO:
- 21 or a sequence at least 90% identical to SEQ ID NO:
- 21;
- (f) an antigen comprising an amino acid sequence corresponding to SEQ ID NO:
- 24 or a sequence at least 90% identical to SEQ ID NO:
- 24;
- (g) an antigen comprising an amino acid sequence corresponding to SEQ ID NO:
- 39 or a sequence at least 90% identical to SEQ ID NO:
- 39;
- (h) an antigen comprising an amino acid sequence corresponding to SEQ ID NO:
- 40 or a sequence at least 90% identical to SEQ ID NO:
- 40;
- (i) an antigen comprising an amino acid sequence corresponding to SEQ ID NO:
- 41 or a sequence at least 90% identical to SEQ ID NO:
- 41;
- and
- (j) an antigen comprising an amino acid sequence corresponding to SEQ ID NO:
- 42 or a sequence at least 90% identical to SEQ ID NO:
- 42.
Dependencies are inferred from the claim text.