Compositions and methods for modulating cholesterol efflux
AssigneeCleveland State University
InventorKAILASH GULSHAN
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Abstract
Compositions and methods for diagnosing, treating, preventing, inhibiting, or ameliorating the symptoms of a disease or disorder that is modulated or otherwise affected by ABCA1 levels and cholesterol efflux or in which ABCA1 levels and cholesterol efflux is implicated are disclosed herein. PIP2 is shown to affect ABCA1 levels and promote RCT leading to reductions in unwanted cholesterol levels and atherosclerosis.
Claims15
A method of treating, preventing, inhibiting, or ameliorating the symptoms of a disease or disorder that is modulated or otherwise affected by ABCA1 levels and cholesterol efflux or in which ABCA1 levels and cholesterol efflux is implicated, the method comprising administering to an individual in need thereof a therapeutically effective amount of PIP2 or an expression vector capable of inducing expression of PIP2 in the individual.
A method of increasing PIP2 level to treat a disease or disorder that is modulated or otherwise affected by ABCA1 levels and cholesterol efflux or in which ABCA1 levels and cholesterol efflux is implicated, the method comprising administering to a subject in need thereof a therapeutically effective amount of PIP2 or an expression vector capable of inducing expression of PIP2 in the individual.
A method of increasing cholesterol efflux from cells of a subject, comprising administering an effective cholesterol efflux-increasing amount of PIP2 or an expression vector capable of inducing expression of PIP2 to an individual in need thereof, wherein the administration increases a level of cholesterol efflux.
Dependencies are inferred from the claim text.