Plasmodium falciparum blood stage inhibitors

A compound comprising Formula I:

• wherein each of R1a—R1e is independently selected from hydrogen, Cl, CH3, OCH3, CH2CH3, CF3, CH(CH3)2, OCF3, OCF2H, CF2H, NH2, C(═O)CF3, S(═O)2CH3, cyclobutyl, cyclopentyl, cyclohexyl, or any combination thereof;
• wherein W1, W2, and W3 are independently N or substituted or unsubstituted C;
• wherein Ar is a 5- or 6-membered aromatic or heteroaromatic ring or a bridged cycloalkyl or heterocycloalkyl ring;
• wherein each of R2a—R2c, if present, is hydrogen, C1-C4 linear or branched alkyl, or when R4 is present, one of R2a—R2c and R4 together form a C1-C4 alkyl bridge;
• wherein X is NR8 or is absent;
• wherein R8 is C1-C4 linear or branched alkyl, CH2CF3, or hydrogen;
• wherein R3 is selected from
• wherein R4 is selected from deuterated or undeuterated C1-C4 linear or branched alkyl;
• hydrogen;
• or together with R5 forms a substituted or unsubstituted cycloalkyl, heterocycloalkyl, aryl, or heteroaryl group containing from 3 to 9 ring atoms, or R4 and one of R2a—R2c together form a C1-C4 alkyl bridge;
• wherein R5 is selected from substituted or unsubstituted C3-C9 cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, or together with R4 forms a substituted or unsubstituted cycloalkyl, heterocycloalkyl, aryl, or heteroaryl group containing from 3 to 9 ring atoms;
• and
• wherein each of R6a—R6e is independently selected from hydrogen, halogen, hydroxyl, cyano, nitro, substituted or unsubstituted C1-C4 linear or branched alkyl, alkoxy, alkylsulfonyl, substituted or unsubstituted amino, substituted or unsubstituted amide, substituted or unsubstituted ketone, or any combination thereof,
• provided the compound of Formula I is not