Pharmaceutical compositions comprising a floating interpenetrating polymer network forming system
AssigneeTris Pharma, Inc.
InventorsParas Rameshlal JAIN, Sachin Vasant CHAUDHARI
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Abstract
Drug delivery systems comprising a floating interpenetrating network (IPN) are provided. The pharmaceutical compositions contain at least one IPN forming system, at least one drug, and at least one gas generating agent, such that upon oral ingestion of the compositions, a floating IPN is formed in situ. These floating IPN provide extended release of the drug entrapped therein for at least about 3 hours.
Claims19
An orally administrable extended release composition which comprises a floating inter-penetrating network (IPN) forming system comprising at least one biologically active moiety selected from a drug, a nutraceutical, a vitamin, a protein, enzyme and/or hormone, and at least one non-toxic gas generating agent, the composition comprising:
- (a) at least one biologically active moiety;
- (b) an inter-penetrating network (IPN) forming blend which self-assembles into a floating IPN in situ following oral ingestion, which comprises:
- (i) at least two polymers comprising at least one IPN forming anionic polymer and/or at least one IPN forming galactomannan;
- (ii) at least one cross-linking agent which interacts with the at least one IPN forming anionic polymer and/or galactomannan (i) to form an IPN and/or a further crosslinked IPN;
- and
- (iii) a non-toxic gas generating agent, wherein the gas generating agent forms a non-toxic gas when exposed to stomach acid,
- wherein following oral ingestion, the composition provides a floating IPN which comprises the at least biologically active one moiety and the non-toxic gas entrapped therein, thereby providing a floating IPN,
- provided that the composition does not include a gamma hydroxy butyrate and its salts, hydrates, tautomers, or solvates, or complexes thereof.
The orally administrable drug composition according to claim, wherein the IPN forming blend comprises at least one anionic polymer and at least a second polymer which are at least partially crosslinked with a crosslinking agent selected from sodium alginate, carrageenan I, pectin, gellan gum, alginic acid, carrageenan k, sodium carboxymethylcellulose, xanthan gum, or combinations thereof.
Dependencies are inferred from the claim text.