Implantable drug-device combinations, and related methods of treatment
AssigneePituvia Therapeutics, Inc.
InventorPatrick J. Fitzgerald
Life of this patent
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Abstract
Provided are drug-device combinations and methods used for direct delivery of therapeutic drugs to the pituitary gland, wherein the drug-device combination also acts as a barrier between a sella turcica (pituitary fossa) and a sphenoid sinus to effectively trap or confine the drug substance within the sella turcica to prevent its premature escape away into the CSF from the target pituitary; thereby reducing or eliminating systemic toxicity of the drug substance. The drug-device combination includes a cap, a stem, a drug that is therapeutically effective for a pituitary gland disorder.
Claims20
A drug-device combination for direct delivery of a drug to a pituitary gland, the drug-device comprising:
- a cap formed of a deformable material, the cap including
- a contact surface forming a base of the cap, the contact surface including an outer perimeter, and
- an upper surface including an apex offset from the contact surface at a cap height, the upper surface extending from the apex to the outer perimeter;
- a stem extending from the contact surface in a direction opposite the apex, wherein the drug-device combination covers a hole formed in a sphenoid bone between a sella turcica and a sphenoid sinus;
- and
- a drug substance that is therapeutically effective for a pituitary gland disorder.
A method of treating a disease by delivering a drug substance directly to a pituitary gland, said method comprising:
- forming a hole in a sphenoid bone that acts as a barrier between a sella turcica and a sphenoid sinus;
- and inserting a drug-device combination implant.
A method for placing a drug-device combination within a pituitary fossa, the method comprising:
- forming a hole in a sphenoid bone that acts as a barrier between a sella turcica and a sphenoid sinus using a surgical tool;
- introducing the drug-device combination into the pituitary fossa via an introducer inserted into the hole;
- withdrawing the introducer;
- and
- surgically closing the hole,
- wherein the drug-device combination comprises a drug substance and an implant and/or microparticle.
A drug-device combination for direct delivery of a drug to a pituitary gland, the drug-device comprising:
- an implant formed of a deformable material;
- and
- a drug substance that is therapeutically effective for a pituitary gland disorder.
Dependencies are inferred from the claim text.