# US 2026/0096831 A1 · Systems, devices, and methods for controlling actuation of tissue resection devices > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2026/0096831 A1 - Document ID: US20260096831A1 - Status: Published application - Kind: A1 - Application number: 19/399,418 - Filed: 2025-11-24 - Published: 2026-04-09 - Earliest claimed: 2024-08-27 - Applicants: Prana Thoracic, Inc. - Inventors: Kenneth M. BUECHE; Ethan FRANCK; Jorge E. SALAZAR; Shane KORTHUIS; Laura K. GONZALEZ - Web page: https://patentgrep.com/patent/US20260096831A1 ## CPC - A61B 17/320016: {Endoscopic cutting instruments, e.g. arthroscopes, resectoscopes (A61B10/0233, A61B17/29, A61B17/3207 take precedence)} - A61B 17/320758: {with a rotating cutting instrument, e.g. motor driven (A61B17/320725, A61B17/32075 and A61B17/320783 take precedence; for removing intra-ocular material A61F9/00763; endoscopic rotatable cutting instruments A61B17/32002)} - A61B 17/12013: {for use in minimally invasive surgery, e.g. endoscopic surgery} - A61B 17/32053: {Punch like cutting instruments, e.g. using a cylindrical or oval knife (A61B17/326 takes precedence; trepans A61B17/1695)} - A61B 18/14: Probes or electrodes therefor - A61B 18/1482: {having a long rigid shaft for accessing the inner body transcutaneously in minimal invasive surgery, e.g. laparoscopy} - A61B 2017/00809: {Lung operations} - A61B 2017/320064: {with tissue or sample retaining means} - A61B 2018/00541: {Lung or bronchi} - A61B 2018/00595: {Cauterization} - A61B 2018/00601: {Cutting} - A61B 2018/141: {Snare} - A61B 2018/142: {at least partly surrounding the target, e.g. concave, curved or in the form of a cave} - A61B 2018/1435: {Spiral} - A61B 2018/1475: {Electrodes retractable in or deployable from a housing} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract In some embodiments, an apparatus includes a handle assembly configured to be coupled to a tissue excision device. The tissue excision device can be configured to excise a target tissue site from a lung. The handle assembly can be configured to transition between a first operation and a second operation mode. The handle assembly in the first operation mode configured to form a portion of a tissue column. The handle assembly in the second operation mode configured to separate the tissue column from surrounding tissue, the handle assembly configured to transition from the first operation mode to the second operation mode after the tissue excision device forms a tissue column including the target tissue site. ## Claims ### Claim 1 An apparatus, comprising: a tissue excision device configured to excise target tissue from a lung, the tissue excision device including one or more tubular members defining an inner volume and configured to advance through lung tissue to form a tissue column within the inner volume that includes the target tissue; and a handle assembly configured to be coupled to the tissue excision device, the handle assembly including a first actuation assembly and a second actuation assembly, the handle assembly configured to transition between a first operation mode and a second operation mode, the first actuation assembly, when the handle assembly is in the first operation mode, configured to cause the one or more tubular members to advance through the lung tissue, seal a portion of the lung tissue, and cut the portion of the lung tissue to form the tissue column, and the second actuation assembly, when the handle assembly is in the second operation mode, configured to cause a snare to separate the tissue column from surrounding tissue. ### Claim 2 (depends on 1) The apparatus of claim 1, wherein the tissue excision device includes: a helical coil coupled to a distal end of a tubular member of the one or more tubular members, the helical coil configured to rotate distally through tissue; a pair of electrodes; and a cutting device configured to cut through the lung tissue. ### Claim 3 (depends on 2) The apparatus of claim 2, wherein when the handle assembly is in the first operation mode, the first actuation assembly is configured to: rotate the helical coil distally through the tissue toward the target tissue; move the pair of electrodes together to clamp tissue between the pair of electrodes; deliver energy to the lung tissue through the pair of electrodes to seal vessels in the portion of the lung tissue; and advance the cutting device to cut the portion of the lung tissue. ### Claim 4 (depends on 2) The apparatus of claim 2, wherein the first actuation assembly includes: a first actuator coupled to the helical coil, the first actuator including a wheel configured to rotate a shaft. ### Claim 5 (depends on 4) The apparatus of claim 4, wherein the first actuation assembly includes: a second actuator configured to move an electrode of the pair of electrodes distally to clamp tissue between the pair of electrodes; and a third actuator coupled to the cutting device and configured to advance the cutting device distally. ### Claim 6 (depends on 5) The apparatus of claim 5, further comprising: a mode button configured to transition the handle assembly from the first operation mode to the second operation mode. ### Claim 7 (depends on 6) The apparatus of claim 6, wherein the mode button when actuated is configured to: expose the snare; and lock the third actuator to prevent the cutting device from being advanced when the handle assembly is in the second operation mode. ### Claim 8 (depends on 2) The apparatus of claim 2, further comprising: a snare actuator configured to be moved to a first position to cause the snare to move a portion of tissue toward the pair of electrodes, the snare actuator configured to be moved to a second position to cause the snare to sever the portion of tissue from the surrounding tissue. ### Claim 9 (depends on 1) The apparatus of claim 1, further comprising: an anchor including a distal end configured to engage the target tissue, the anchor configured to guide the tissue excision device toward the target tissue. ### Claim 10 (depends on 9) The apparatus of claim 9, wherein the handle assembly is configured to be transitioned from the first operation mode to the second operation mode after a proximal portion of the anchor engages a portion of the handle assembly indicating the target tissue is disposed in the inner volume of the one or more tubular members. ### Claim 11 An apparatus, comprising: a first actuator coupled to a helical coil of a tissue excision device, the helical coil including a first electrode on a surface thereof, the first actuator configured to rotate a shaft coupled to the helical coil to cause the helical coil to rotate distally through tissue; a second actuator coupled to a tubular assembly including a second electrode on a distal end thereof, the second actuator configured to apply a first force to the tubular assembly to move the tubular assembly distally to clamp a portion of tissue between the first electrode and the second electrode, the first electrode and the second electrode configured to be activated with energy to seal vessels in the portion of tissue when the portion of tissue is clamped between the first electrode and the second electrode; and a third actuator coupled to the tubular assembly, the third actuator configured to apply a second force to the tubular assembly after the portion of tissue is sealed to cause a cutting device disposed within the tubular assembly to advance through the portion of tissue to cut the portion of tissue. ### Claim 12 (depends on 11) The apparatus of claim 11, further comprising: a mode button configured cause the tubular assembly to withdraw proximally to expose a snare near the distal end of the tubular assembly. ### Claim 13 (depends on 12) The apparatus of claim 12, wherein the portion of tissue is a first portion of tissue, the apparatus further comprising: a snare actuator configured to be moved to a first position to cause the snare to move a second portion of tissue toward the first electrode and the second electrode, the snare actuator configured to be moved to a second position to cause the snare to sever the second portion of tissue from surrounding tissue. ### Claim 14 (depends on 11) The apparatus of claim 11, wherein the tissue is lung tissue, the apparatus further comprising: a locking mechanism, the locking mechanism in a locked configuration configured to prevent movement of the first actuator, the locking mechanism configured to transition to a locked configuration when a distal end of the helical coil is at a predetermined depth relative to a surface of a lung. ### Claim 15 (depends on 11) The apparatus of claim 11, wherein the tubular assembly and the cutting device are connected at a proximal end, the second actuator configured to apply the first force and the third actuator configured to apply the second force to the proximal end. ### Claim 16 (depends on 15) The apparatus of claim 15, wherein the second force is greater than the first force. ### Claim 17 (depends on 15) The apparatus of claim 15, wherein a portion of the tubular assembly includes a plurality of cut outs such that the portion of the tubular assembly is compliant along a longitudinal axis thereof, the second force applied to the proximal end configured to cause the portion of the tubular assembly to compress along the longitudinal axis. ### Claim 18 An apparatus, comprising one or more actuators configured to cause one or more tubular members to advance through lung tissue, seal a portion of the lung tissue, and cut the portion of the lung tissue to form a tissue column in an inner volume defined by the one or more tubular members; a retraction mechanism configured to cause the one or more tubular members to withdraw proximally to expose a snare near a distal end of the one or more tubular members; and a snare actuator moveable to a first position to cause the snare to move a distal portion of the tissue column toward a first electrode and a second electrode such that the first electrode and the second electrode can seal the distal portion of the tissue column, the snare actuator further moveable from the first position to a second position to cause the snare to sever the tissue column from surrounding tissue. ### Claim 19 (depends on 18) The apparatus of claim 18, wherein the one or more actuators includes a first actuator coupled to a helical coil including a first electrode and configured to cause the helical coil to rotate distally through tissue; and a second actuator coupled to a tubular member including a second electrode on a distal end thereof, the second actuator configured to cause the tubular member to move distally to clamp tissue between the first electrode and the second electrode. ### Claim 20 (depends on 19) The apparatus of claim 19, wherein the one or more actuators includes a third actuator coupled to a cutting device, the third actuator configured to cause the cutting device to advance through the clamped tissue to cut the clamped tissue. ### Claim 21 (depends on 20) The apparatus of claim 20, wherein the retraction mechanism is configured such that the third actuator is locked, after the snare is exposed, to prevent the cutting device from being advanced. ### Claim 22 (depends on 20) The apparatus of claim 20, wherein the second actuator and the third actuator are each a lever. ### Claim 23 (depends on 20) The apparatus of claim 20, wherein the tubular member and the cutting device are connected at a proximal end, the second actuator configured to apply a first force and the third actuator configured to apply a second force to the proximal end. ### Claim 24 (depends on 23) The apparatus of claim 23, wherein the second force is greater than the first force. ### Claim 25 (depends on 23) The apparatus of claim 23, wherein the tubular member includes a plurality of cut outs such that the tubular member is compliant along a longitudinal axis of the tubular member, the second force applied to the proximal end configured to cause the tubular member to compress along the longitudinal axis. ### Claim 26 An apparatus, comprising: a housing defining an inner volume; an actuator disposed on the housing and coupled to a tubular member, the actuator configured to cause the tubular member to rotate distally through tissue of a lung; a locking mechanism at least partially disposed in the housing, the locking mechanism in a locked configuration configured to prevent movement of the actuator, the locking mechanism configured to transition from an unlocked configuration to the locked configuration when a distal end of the tubular member is at a predetermined depth relative to a surface of the lung; and a shaft configured to extend through the inner volume of the housing such that a portion of the shaft is slidably disposed through a portion of the locking mechanism, the shaft coupled to a tissue anchor configured to anchor to a target tissue site in the lung, the shaft including a groove configured to engage with the portion of the locking mechanism when the distal end of the tubular member is at the predetermined depth, to transition the locking mechanism to the locked configuration. ### Claim 27 (depends on 26) The apparatus of claim 26, wherein the tubular member is a first tubular member including a first electrode on a distal end thereof, the apparatus further comprising: a second actuator coupled to a second tubular member including a second electrode on a distal end thereof, the second actuator configured to apply a first force to the second tubular member to move the second tubular member distally to clamp a portion of tissue between the first electrode and the second electrode, the first electrode and the second electrode configured to be activated with energy to seal vessels in the portion of tissue. ### Claim 28 (depends on 27) The apparatus of claim 27, further comprising: a third actuator coupled to a cutting device, the third actuator when actuated configured to apply a second force to the cutting device to cause the cutting device to advance through the portion of tissue and cut the portion of tissue. ### Claim 29 (depends on 27) The apparatus of claim 27, further comprising a mode button, the mode button is configured to cause the second tubular member to withdraw proximally to expose a snare near a distal end of the second tubular member. ### Claim 30 (depends on 29) The apparatus of claim 29, wherein the portion of tissue is a first portion of tissue, the apparatus further comprising: a snare actuator configured to be moved to a first position to cause the snare to move a second portion of tissue toward the first electrode and the second electrode, the snare actuator configured to be moved to a second position to cause the snare to sever the second portion of tissue from surrounding tissue.